Evidence map›Paper›PMID 40665964›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2025

High-performance dual-ended SiPM readout for TOF-PET with BGO and LYSO:Ce.

Nicolaus Kratochwil, Emilie Roncali, Joshua W Cates, Gerard Ariño-Estrada

Abstract read
In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Current Status of Cherenkov-Based Gamma Detectors for TOF-PET and Proton Range Verification.IEEE transactions on radiation and plasma medical sciences · 2026
    Article
  4. Optical crosstalk between SiPMs in dual-ended readout.Sensors and actuators. A, Physical · 2025
    Article
  5. TlCl:Be,I: a high sensitivity scintillation and Cherenkov radiator for TOF-PET.IEEE transactions on radiation and plasma medical sciences · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicolaus KratochwilDepartment of Biomedical Engineering, University of California at Davis (UCD), Davis, CA, United States.ORCID 0000-0001-5297-1878
Emilie RoncaliDepartment of Biomedical Engineering and with the Department of Radiology at UCD.ORCID 0000-0002-2439-1064
Joshua W CatesLawrence Berkeley National Laboratory, Berkeley, CA, United States.ORCID 0000-0002-5649-8691
Gerard Ariño-EstradaDepartment of Biomedical Engineering at UCD and with the Institut de Física d'Altes Energies - Barcelona Institute of Science and Technology, Bellaterra, Barcelona, Spain.ORCID 0000-0002-6411-191X

Funding

TOF-PET with high-efficiency TlCl crystalsR01EB034062 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Gerard Arino Estrada · 2023 to 2026
$2.5M
Low cost and high performance time-of-flight PET detectorsR01EB028286 · NIBIB · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CATES, JOSHUA WILLIAM · 2020 to 2023
$1.9M
NIBIB NIH HHS R01 EB028286NIBIB NIH HHS R01 EB034062
6 · The paper itself

Abstract

Detection time performance is a key aspect for time-of-flight positron emission tomography. With recent advancement in SiPM technology and fast readout electronics, one limiting factor on timing performance is light transport in the crystal. For high aspect-ratio crystals with single-ended readout, the time information of approximately half the optical photons is severely degraded as they initially travel in the direction opposed to the photodetector. For promptly-emitted Cherenkov photons, the increase of variance of optical path length limits their intrinsic advantage. Low-noise and high-frequency dual-ended SiPM readout can be employed to mitigate the aforementioned challenges and has the potential to combine ultra-fast timing with highest gamma-ray detection efficiency. We have studied the timing properties of cerium-doped lutetium-yttrium-oxyorthosilicate (LYSO:Ce) and bismuth germanate (BGO) in a symmetric dual-ended SiPM readout configuration. A time-based depth-of-interaction correction and a novel adaptive timestamp weighting was used to optimize the timing performance. Coupling 3×3×20 mm

Indexed as

Cherenkov emission in BGOdepth-of-interaction (DOI) correctiondual-ended SiPM readoutfast timinglight transportsilicon photomultiplier (SiPM)time-of-flight positron emission tomography (TOF-PET)

Identifiers

PMID40665964
PMCPMC12262056

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.