ArticleJournal of cosmetic dermatology2025
Imaging 1927 nm Fractional Thulium Laser-Tissue Interactions: A Spectrum of Nonablative to Ablative Effects.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Comparative Efficacy and Safety of 1064-nm Picosecond Laser and 1927-nm Fractional Thulium Laser for Atrophic Acne Scars in Asian Patients: A Prospective, Randomized, Split-Face Study.Lasers in surgery and medicine · 2026Trial
- Photothermal interaction of a 1927 nm Thulium laser with MatriDerm: an in vitro study.Lasers in medical science · 2026Article
- Clinical and Histopathological Assessment of the Field of Cancerization in Human Skin Before and After Treatment With a 1927-nm Thulium Fractional Laser.Lasers in surgery and medicine · 2026Observational
- Imaging 1927 nm Fractional Thulium Laser-Tissue Interactions: A Spectrum of Nonablative to Ablative Effects.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundInfrared fractional lasers that target tissue water are traditionally divided into nonablative and ablative devices. The 1927 nm fractional thulium fiber laser (FTL) may, due to an intermediate water absorption coefficient, offer a range of nonablative-to-ablative effects.
objectiveThis study explored dynamic 1927 nm FTL-tissue interactions produced by different pulse energies in in vivo human skin, using non-invasive optical coherence tomography (OCT) and line-field confocal OCT (LC-OCT) imaging.
methodsFTL exposure was performed on in vivo antero-lateral forearm skin at 0, 3, 15, or 20 mJ pulse energy using two separate laser tips (spot size: 200 μm (C1); 350 μm (C5)) at 20-watt power. Immediately after, LC-OCT and OCT imaging enabled qualitative description of microthermal treatment zone (MTZ) morphology, as well as semiquantitative measurement of MTZ diameter and ablation depth.
resultsRanging from nonablative subepidermal effects to frank ablation, imaging revealed a variety of MTZ morphologies depending on pulse energy and laser tip. At low 3 mJ pulse energy, effects were generally limited to the epidermis, with MTZs consisting of subepidermal clefts (C5) or disruptions through the viable epidermis (C1) under a residual stratum corneum. Rising 15-20 mJ pulse energies expanded thermal effects in the lateral and vertical plane, leading to wider MTZs (e.g., C1: 3 mJ vs. 20 mJ: 213 vs. 357 μm), more extensive stratum corneum involvement, and increasing ablation depth to the superficial dermis (e.g., C1: 3 mJ vs. 20 mJ: 93 vs. 101 μm).
conclusionVisualized by combined LC-OCT and OCT imaging, FTL-tissue interactions are highly modifiable and span the nonablative to ablative spectrum depending on pulse energy and laser tip.
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