Evidence map›Paper›PMID 40665742›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2025

Baseline predictors of poor clinical outcome despite recanalization of distal middle cerebral artery occlusions.

Imene Chafai, Hamza Salim, Basel Musmar, Nimer Adeeb, Vivek Yedavalli, Kareem ElNaamani, Nils Henninger, Simona Nedelcu, Sri Hari Sundararajan, Anna Luisa Kühn and 53 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

63 authors.

Imene ChafaiDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.ORCID 0009-0006-3500-9015
Hamza SalimDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.ORCID 0000-0002-5208-8425
Basel MusmarDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.ORCID 0009-0000-4910-6090
Nimer AdeebDepartment of Neurosurgery and Interventional Neuroradiology, Louisiana State University, Shreveport, LA, USA.ORCID 0000-0002-8668-7629
Vivek YedavalliDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.ORCID 0000-0002-2450-4014
Kareem ElNaamaniDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-1054-9414
Nils HenningerDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3883-5623
Simona NedelcuDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-5473-1368
Sri Hari SundararajanDepartment of Endovascular Neurosurgery and Neuroradiology, Rutgers Health New Jersey Medical School (NJMS), Newark, NJ, USA.
Anna Luisa KühnDivision of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA.ORCID 0000-0001-9512-9461
Jane KhalifeCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA.ORCID 0000-0003-3662-3886
Sherief GhozyDepartments of Neurological Surgery & Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5629-3023
Luca ScarciaDepartment of Neuroradiology, Henri Mondor Hospital, Creteil, France.ORCID 0000-0002-1316-0383
Benjamin Yq TanDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0003-1824-9077
Jeremy Josef HeitDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, California, USA.ORCID 0000-0003-1055-8000
Robert W RegenhardtNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.ORCID 0000-0003-2958-3484
Nicole M CancelliereNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0002-8703-4304
Joshua D BernstockDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7814-3867
Aymeric RouchaudUniversity Hospital of Limoges, Neuroradiology Department, Dupuytren, Université de Limoges, XLIM CNRS, UMR, France.ORCID 0000-0003-0902-3375
Jens FiehlerCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA.ORCID 0000-0001-8533-7478
Sunil A ShethDepartment of Neurology, UTHealth McGovern Medical School, Houston, TX, USA.ORCID 0000-0003-0602-8509
Muhammed Amir EssibayiDepartment of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0001-8325-2382
Ajit S PuriDivision of Neurointerventional Radiology, Department of Radiology, University of Massachusetts Medical Center, Worcester, MA, USA.
Christian DyzmannNeuroradiology Department, Sana Kliniken, Lübeck GmbH, Lübeck, Germany.
Marco ColasurdoDepartment of Interventional Radiology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-7823-3088
Gaultier MarnatInterventional Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.ORCID 0000-0002-7611-7753
Leonardo RenieriInterventistica Neurovascolare, Ospedale Careggi di Firenze, Florence, Italy.ORCID 0000-0001-8966-8266
João Pedro FilipeDepartment of Diagnostic and Interventional Neuroradiology, Centro Hospitalar Universitário do Porto, Porto, Portugal.ORCID 0000-0002-7232-9820
Pablo HarkerDepartment of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-0263-8748
Răzvan Alexandru RaduDepartment of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.ORCID 0000-0001-6375-8466
Thomas R MarottaNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0002-2480-2054
Julian SpearsNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0002-4111-6929
Takahiro OtaDepartment of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.ORCID 0000-0002-5108-6719
Ashkan MowlaDivision of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA.ORCID 0000-0001-5352-8747
Pascal JabbourDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-8965-2413
Arundhati BiswasDepartment of Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY, USA.
Frédéric ClarençonDepartment of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.ORCID 0000-0002-6442-8239
Thanh N NguyenDepartments of Radiology & Neurology, Boston Medical Center, Boston, MA, USA.ORCID 0000-0002-2810-1685
Ricardo VarelaDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, Portugal.ORCID 0000-0002-8072-1013
Amanda BakerDepartment of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
David AltschulDepartment of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-5130-1378
Nestor GonzalezDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-8277-6317
Markus A MöhlenbruchSektion Vaskuläre und Interventionelle Neuroradiologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID 0000-0002-5075-704X
V CostalatDepartment of Neuroradiology, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.
Benjamin GoryDepartment of Interventional Neuroradiology, Nancy University Hospital, Nancy, France.ORCID 0000-0001-8424-4464
Paul StrackeDepartment of Radiology, Interventional Neuroradiology Section, University Medical Center Münster, Münster, Germany.ORCID 0000-0003-1242-4372
Mohammad A Aziz-SultanDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Constantin HeckerDepartments of Neurology & Neurosurgery, Christian Doppler Clinic, Paracelsus Medical University Salzburg, Salzburg, Austria.ORCID 0000-0003-0521-8570
Hamza ShaikhCooper Neurological Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA.ORCID 0000-0001-8163-4600
David S LiebeskindUCLA Stroke Center and Department of Neurology Department, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-5109-8736
Alessandro PedicelliUOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Roma, Italy.ORCID 0000-0002-2558-8838
Andrea Maria AlexandreUOSA Neuroradiologia Interventistica, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Roma, Italy.ORCID 0000-0002-8080-3916
Illario TancrediDepartment of Neurology, Hôpital Civil Marie Curie, Charleroi, Belgium.ORCID 0000-0001-5190-2635
Tobias D FaizyDepartment of Radiology, Neuroendovascular Program, University Medical Center Münster, Münster, Germany.ORCID 0000-0002-1631-2020
Erwah KalsoumDepartment of Neurology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-8575-0606
Aman B PatelNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Robert FahedDepartment of Medicine - Division of Neurology; The Ottawa Hospital, Ottawa Hospital Research Institute and University of Ottawa, Ottawa-Ontario, Canada.ORCID 0000-0002-1887-5097
Maud WangDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.ORCID 0000-0003-4216-9958
Vitor Mendes PereiraNeurovascular Centre, Divisions of Therapeutic Neuroradiology and Neurosurgery, St Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0002-6804-3985
Boris LubiczDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.ORCID 0000-0001-8312-2115
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.ORCID 0000-0003-0131-5699
Adrien GuenegoDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.ORCID 0000-0001-7281-1652
MAD MT Investigators ##

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveMechanical thrombectomy (MT) is well-established for the treatment of acute ischemic stroke (AIS) from large vessel occlusion (LVO), with growing data supporting the expansion to distal and medium vessel occlusions (DMVO). Despite successful recanalization in DMVO, certain patients still experience poor long-term clinical outcomes, prompting our study to comprehensively explore pre-MT factors influencing outcome despite excellent recanalization (final modified Thrombolysis in Cerebral Infarction [mTICI] score ≥2c).MethodsWe retrospectively examined data from patients who consecutively underwent MT for a primary middle cerebral artery (MCA) DMVO across 37 centers in North America, Asia, and Europe. We identified baseline clinical and imaging factors associated with poor clinical outcome (defined as a modified Rankin Scale [mRS] score of 3-6) at 3 months, despite excellent recanalization using a multivariable model.ResultsBetween September 2017 and July 2021, 623 patients achieved mTICI > 2b and they were included in our study. Among them, 198 (32%) experienced a poor clinical outcome (mRS 3-6). Predictors of poor clinical outcome included higher age (OR 1.05 [1.03-1.07],

Indexed as

Distal and medium vessel occlusionsischemic strokemechanical thrombectomymedium vessel occlusionstroke outcomes

Identifiers

PMID40665742
PMCPMC12267219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.