ArticleActa anaesthesiologica Scandinavica2025
The Beneficial and Harmful Effects of Perioperative Clonidine: Protocol for a Systematic Review With Meta-Analysis.
Article in Acta anaesthesiologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical Efficacy and Risks of Clonidine Infusion for Sedation and Analgesia: A Narrative Review.Current pain and headache reports · 2026Review
- The Beneficial and Harmful Effects of Perioperative Clonidine: Protocol for a Systematic Review With Meta-Analysis.Acta anaesthesiologica Scandinavica · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundModerate to severe postoperative pain is frequent in patients undergoing surgery and is associated with increased morbidity and prolonged hospitalisation. Therefore, sufficient pain management should be prioritised. Clonidine, an alpha-2 agonist with analgesic properties, may represent a relevant option in postoperative pain management. While clonidine is commonly used in a clinical setting, the quality of evidence supporting its perioperative use is limited by small sample sizes, heterogeneous study designs, and variations in administration routes. This systematic review aims to evaluate the benefits and harms of perioperative clonidine in postoperative pain management.
methodsWe will conduct a systematic review of randomised clinical trials assessing the effects of perioperative clonidine on postoperative pain intensity, adverse effects, and postoperative opioid consumption. This review will include trials using perioperative systemic (oral, intravenous, transdermal, or intramuscular) clonidine and trials using placebo or no intervention as the control intervention. We will systematically search Medline, Embase, and the Cochrane Central Register of controlled trials for relevant literature. The recommendations by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) are followed for this protocol, and the PRISMA guidelines will be followed in the actual review. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. OUTCOMES: The primary outcomes are postoperative pain intensity and serious adverse events. Secondary outcomes include postoperative opioid consumption, quality of life, and non-serious adverse events. DISCUSSION: Although clonidine is used in a clinical setting to manage postoperative pain, the benefits and harms of this intervention remain unclear.
conclusionThis systematic review will provide valuable information on the efficacy and safety of perioperative clonidine in postoperative pain management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.