Evidence map›Paper›PMID 40665679›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2025

Characterizing pre- and post-operative cerebral blood flow and transit time in pediatric moyamoya patients using multi-delay ASL and DSC MRI.

Moss Y Zhao, Sasha Alexander, Chris Antonio Lopez, Helena Zhang, Gabriella Morton, Rui Duarte Armindo, Kristen W Yeom, Elizabeth Tong, Bruno P Soares, Sarah Lee and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Moss Y ZhaoDepartment of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0210-7739
Sasha AlexanderDepartment of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, CA, USA.
Chris Antonio LopezDepartment of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, CA, USA.
Helena ZhangDepartment of Radiology, Stanford University, Stanford, CA, USA.
Gabriella MortonDepartment of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, CA, USA.ORCID 0009-0005-9884-3069
Rui Duarte ArmindoDepartment of Radiology, Stanford University, Stanford, CA, USA.
Kristen W YeomDepartment of Radiology, Stanford University, Stanford, CA, USA.
Elizabeth TongDepartment of Radiology, Stanford University, Stanford, CA, USA.
Bruno P SoaresDepartment of Radiology, Stanford University, Stanford, CA, USA.
Sarah LeeDepartment of Neurology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8821-6636
Michael MoseleyDepartment of Radiology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9163-8741
Gary K SteinbergDepartment of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6374-1058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral blood flow (CBF) and transit time are essential biomarkers for assessing brain health. While dynamic susceptibility contrast (DSC) MRI has been widely applied to measure these metrics, it is limited in the pediatric population due to the need for contrast agents. Arterial spin labeling is a non-invasive and quantitative MR modality, and multi-delay ASL can measure CBF and transit time simultaneously. Although multi-delay ASL has been used in adult neuroimaging studies, its application in children requires investigation. Moyamoya disease, a progressive steno-occlusive cerebrovascular disorder, often manifests in childhood. In this work, we present a cohort study that examines multi-delay ASL and DSC MRI to characterize vascular hemodynamics in 22 pediatric patients. We evaluate CBF and transit time in different brain regions before and after revascularization surgeries. Results show that revascularization significantly increased CBF by 24% and 7.6%, respectively, as measured by ASL and DSC; it also significantly decreased transit time by 12% and 15%, indicating improved hemodynamics and metabolism. ASL and DSC results also showed significantly positive correlations in all brain regions. Thus, revascularization improved hemodynamics in pediatric moyamoya patients and shows that multi-delay ASL can effectively characterize CBF and transit time in the pediatric population.

Indexed as

Cerebrovascular CirculationMagnetic Resonance ImagingMoyamoya DiseaseAdolescentBrainCerebral RevascularizationChildChild, PreschoolCohort StudiesFemaleHemodynamicsHumansMaleSpin LabelsSpin Labelsarterial spin labelingarterial transit timeCerebral blood flowdynamic susceptibility contrastmoyamoya disease

Identifiers

PMID40665679
PMCPMC12267206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.