Evidence map›Paper›PMID 40665675›Full record

SynthesisJournal of the International Association of Providers of AIDS Care

Epidemiology of Antiretroviral Therapy Related Adverse Drug Reactions and its Predictors Among Patients with Human Immunodeficiency Virus/AIDS in Ethiopia: A Systematic Review and Meta-analysis.

Woretaw S Zewdu, Samuel B Dagnew, Mulugeta M Zeleke, Yared A Ferede, Achenef B Kassie, Tilay A Moges, Muluken A Alemu

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the International Association of Providers of AIDS Care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Woretaw S ZewduDepartment of Pharmacology and Toxicology, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0003-2616-4014
Samuel B DagnewDepartment of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0002-8938-4551
Mulugeta M ZelekeDepartment of Pharmacology and Toxicology, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0001-7904-5823
Yared A FeredeDepartment of Pharmacology and Toxicology, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0002-4801-4976
Achenef B KassieDepartment of Pharmacology and Toxicology, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0003-4697-7303
Tilay A MogesDepartment of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0001-6813-8792
Muluken A AlemuDepartment of Pharmacology and Toxicology, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0002-1540-3369

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveAdverse drug reactions (ADRs) induce iatrogenic harm in antiretroviral therapy (ART) care continuum. However, there is a dearth of concrete evidence in a resource-limited setting. Thus, this study was designed to consolidate existing knowledge, thereby informing policy and clinical care to improve patient safety.DesignSystematic review and meta-analysis.Data sourcesPubMed, CINAHL, Web of Science, and EMBASE databases were searched.Eligibility criteriaEmploying the condition, context, and population framework, observational primary studies were included.Data extraction and synthesisIndependent reviewers undertook data extraction and synthesis. This meta-analysis employed the random-effects restricted maximum likelihood (REML) method, with its protocol preregistered on the International Register of Systematic Reviews (CRD42024546390).ResultsThe pooled prevalence of ADRs was 36.7% [95% CI: 26.6-46.9,

Indexed as

Acquired Immunodeficiency SyndromeAnti-HIV AgentsAnti-Retroviral AgentsDrug-Related Side Effects and Adverse ReactionsHIV InfectionsEthiopiaHumansPrevalenceAnti-HIV AgentsAnti-Retroviral Agentsadverse drug reactionantiretroviral therapyhighly active antiretroviral therapyhuman immunodeficiency virus/AIDSpatient safety

Identifiers

PMID40665675
PMCPMC12268142

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.