ArticleCancer reports (Hoboken, N.J.)2025
Penile Cancer Distant Metastasis or Primary Lung Cancer? Using Focused Genomic Profiling of Tumor and Germline Mutations With Next-Generation Sequencing for Clinical Decision-Making.
Article in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of a distant metastasis in penile squamous cell carcinoma (PSCC) is associated with a very poor prognosis. When isolated distant tumors are detected in patients with known PSCC, it is therefore important to accurately determine whether such lesions represent penile cancer metastasis or indeed a new primary cancer. This distinction can have a significant influence on both patient prognostication as well as recommended treatment regimens. CASES: In this case series, we present three patients surgically treated for inguinal node-positive PSCC. Two of the patients developed isolated lesions in the right hilar lymph nodes within 14 months after surgery, and one patient had a concurrent lesion in the right upper lobe at the time of diagnosis. None of the standard radiological or histopathological examinations could truly identify the origin of these lesions. Moreover, neither could biomarker analysis with p16
conclusionFocused NGS analysis of tumor tissue can provide molecular insights that may help clarify the possible origin of thoracic tumors in patients with PSCC. The results may support clinical decision-making and also be used for prognostication and patient counseling.
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