Evidence map›Paper›PMID 40665627›Full record

ArticleVirulence2025

IscR-tmRNA regulatory axis plays a key role in multiple stress response and pathogenicity in

Xiang Ma, Yuan Tong, Pingwei Gao, Lingmin Sun, Hong Li, Yanqiong Tang, Juanjuan Li, Xue Chi, Zhu Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiang MaYunnan Provincial Key Laboratory of Animal Nutrition and Feed, Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.ORCID 0000-0003-0103-861X
Yuan TongPathogenesis and Control of Pathogenic Microorganisms Research Team, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Pingwei GaoPathogenesis and Control of Pathogenic Microorganisms Research Team, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Lingmin SunPathogenesis and Control of Pathogenic Microorganisms Research Team, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Hong LiPathogenesis and Control of Pathogenic Microorganisms Research Team, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Yanqiong TangPathogenesis and Control of Pathogenic Microorganisms Research Team, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Juanjuan LiPathogenesis and Control of Pathogenic Microorganisms Research Team, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Xue ChiPathogenesis and Control of Pathogenic Microorganisms Research Team, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Zhu LiuYunnan Provincial Key Laboratory of Animal Nutrition and Feed, Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.ORCID 0009-0003-2332-1333

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial pathogens intricately modulate their response to a variety of stress and the virulence, particularly in light of the dynamic conditions both in natural habitat and within host organisms. Transfer-messenger RNA (tmRNA), which plays an important role in pathogenicity due to its major function in the trans-translation system for ribosome rescue, has been proved as a stress response molecule. Herein, our results indicate that the global regulator IscR acts as a crucial activator responsible for the expression of tmRNA in

Indexed as

Aeromonas veroniiBacterial ProteinsGene Expression Regulation, BacterialRNA, BacterialStress, PhysiologicalAnimalsFemaleGram-Negative Bacterial InfectionsMiceMice, Inbred BALB COxidative StressPromoter Regions, GeneticVirulenceBacterial ProteinsRNA, BacterialtmRNAAeromonas veroniiIscRpathogenicitystress responsetmRNAvirulence

Identifiers

PMID40665627
PMCPMC12269673

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.