Evidence map›Paper›PMID 40665605›Full record

ArticleMedical physics2025

Microdosimetry calculations in situ for clinically relevant photon sources and their correlation with the early DNA damage response.

Mirta Dumančić, Jonathan Kalinowski, Victor D Diaz-Martinez, Joanna Li, Behnaz Behmand, Joseph M DeCunha, Shirin A Enger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mirta DumančićMedical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0009-0002-1407-488X
Jonathan KalinowskiMedical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0009-0000-5501-618X
Victor D Diaz-MartinezMedical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Joanna LiMedical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0001-6746-8722
Behnaz BehmandMedical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Joseph M DeCunhaMedical Physics Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, USA.ORCID https://orcid.org/0000-0003-2098-4222
Shirin A EngerMedical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0002-6037-0615

Funding

Alpha Tau Medical Ltd.Canada Research Chairs 252135Institut TransMedTechMcGill University Health CentreMEDTEQ+
6 · The paper itself

Abstract

backgroundRadiobiological data suggests variations in relative biological effectiveness (RBE) between clinically used photon-based sources. A microdosimetric formalism using Monte Carlo (MC) methods can mechanistically describe the photon RBE. Experimentally derived RBE based on DNA double-strand breaks ( PURPOSE: To calculate microdosimetric spectra for clinically relevant photon sources, spanning from soft x-rays produced by a 50 kVp x-ray source through various brachytherapy sources up to a 6 MV medical linac. Furthermore, we investigated the correlation between

methodsPhoton sources simulated include low-energy x-rays (50 kVp), orthovoltage x-rays (225 kVp), high-dose-rate brachytherapy sources (

resultsThe calculated

conclusionsMicrodosimetric spectra strongly depend on the simulated energy of photon sources and target size, with

Indexed as

DNA DamagePhotonsRadiometryBrachytherapyDNA Breaks, Double-StrandedHumansMonte Carlo MethodRelative Biological Effectivenessdouble‐strand breaksmicrodosimetrymultiscale dosimetryrelative biological effectiveness

Identifiers

PMID40665605
PMCPMC12272329

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.