ArticleMedical physics2025
Impact of intracellular radionuclide distribution in a Monte Carlo biophysical 3D multi-cellular model for targeted alpha therapy.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- An analytical framework for efficient and precision-controlled Monte Carlo simulation of heterogeneous targeted alpha therapy microdosimetry.Medical physics · 2026Article
- Impact of intracellular radionuclide distribution in a Monte Carlo biophysical 3D multi-cellular model for targeted alpha therapy.Medical physics · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundTo understand and predict the therapeutic efficacy of targeted alpha therapy (TAT), nano- and microdosimetry are needed to consider the very heterogeneous dose deposition at cellular and subcellular levels. PURPOSE: The objective of this study is to theoretically evaluate the importance of cell internalization of alpha-emitters on relevant dosimetric and biological endpoints.
methodsIsolated cells and realistic 3D multi-cellular geometries (spheroids modeled with CPOP) were generated as well as distributions of alpha-emitters corresponding to various cellular internalization cases. The alpha particles emitted were tracked with Geant4 (Monte Carlo) simulations. We calculated mean specific energies deposited into each cell nucleus (
resultsFor a given activity per cell (APC), the radionuclide distribution had a critical influence on
conclusionsAccording to these findings, a precise modeling of alpha-emitter intracellular distributions may be required for small micro-metastases or tumors presenting regions with relatively low radionuclide concentration in order to limit the prediction uncertainties on biological outputs. Intratumoral fluctuations of APC were also found to be a critical parameter to consider for therapeutic efficacy prediction in TAT.
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