Evidence map›Paper›PMID 40665569›Full record

ArticleMedical physics2025

Exploring the potential of Raman micro-spectroscopy of radiochromic films for experimental microdosimetry.

Connor McNairn, Prarthana Pasricha, Kirsty Milligan, Iymad R Mansour, Edana Cassol, Vinita Chauhan, Jeffrey L Andrews, Sanjeena Subedi, Andrew Jirasek, Bryan R Muir and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Connor McNairnDepartment of Physics, Carleton University, Ottawa, Ontario, Canada.
Prarthana PasrichaDepartment of Physics, Carleton University, Ottawa, Ontario, Canada.
Kirsty MilliganDepartment of Physics, University of British Columbia - Okanagan Campus, Kelowna, Canada.
Iymad R MansourDepartment of Physics, Carleton University, Ottawa, Ontario, Canada.
Edana CassolDepartment of Health Sciences, Carleton University, Ottawa, Ontario, Canada.
Vinita ChauhanConsumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada.
Jeffrey L AndrewsDepartment of Statistics, University of British Columbia University of British Columbia - Okanagan Campus, Kelowna, Canada.
Sanjeena SubediDepartment of Statistics, Carleton University, Ottawa, Ontario, Canada.
Andrew JirasekDepartment of Physics, University of British Columbia - Okanagan Campus, Kelowna, Canada.
Bryan R MuirMetrology Research Centre, National Research Council of Canada, Ottawa, Ontario, Canada.
Rowan M ThomsonDepartment of Physics, Carleton University, Ottawa, Ontario, Canada.
Sangeeta MurugkarDepartment of Physics, Carleton University, Ottawa, Ontario, Canada.

Funding

Government of Canada's New Frontiers in Research Fund (NFRF) NFRFE-2021-00312Natural Sciences and Engineering Research Council (NSERC) of Canada RGPIN-2020-04646(JLA)Natural Sciences and Engineering Research Council (NSERC) of Canada RGPIN-2020-07232(AJ)Natural Sciences and Engineering Research Council (NSERC) of Canada RGPIN-2021-03812(SS)Natural Sciences and Engineering Research Council (NSERC) of Canada RGPIN-2022-04897(SM)Natural Sciences and Engineering Research Council (NSERC) of Canada RGPIN-2024-05355(RMT)
6 · The paper itself

Abstract

backgroundMicrometer-scale dosimetry is crucial when estimating the energy deposited within micrometer-scale biological targets exposed to low doses or high dose gradients. Raman micro-spectroscopy read-out of radiochromic films (RCFs) permits micrometer-scale resolution; this presents a novel opportunity to explore its feasibility for experimental microdosimetry. PURPOSE: The purpose of this work was to develop a novel approach towards generating data for experimental microdosimetry. The objective was to develop a method based on high (1-2 µm) spatial resolution Raman micro-spectroscopy of RCFs, ensuring reproducibility of data while producing two-dimensional intensity maps of the Raman response.

methodsEBT3 RCFs were irradiated to doses between 0.2 Gy and 2 Gy using a clinical linear accelerator. Raman spectra were collected using a custom Raman microscope fitted with 40× and 60× water immersion (WI) objectives, and a commercial Raman microscope utilizing a 100× dry objective. The excitation source of the custom setup was circularly polarized to minimize the influence of polarization on the film read-out. The Raman response of the RCFs was measured over a 100 × 100 µm

resultsThe dose response of each Raman microscope setup over the 0-2 Gy dose range was linear (r

conclusionsThis work explored the feasibility of a Raman micro-spectroscopy-based read-out technique of RCFs for experimental microdosimetry. Utilizing the 2260 cm

Indexed as

Film DosimetrySpectrum Analysis, Ramanfilm heterogeneityhigh spatial resolution dosimetryradiochromic filmRaman micro‐spectroscopy

Identifiers

PMID40665569
PMCPMC12264321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.