Evidence map›Paper›PMID 40665555›Full record

ArticleMedical physics2025

Report on the quantitative intra-voxel incoherent motion diffusion MRI reconstruction grand challenge.

Xiaoyu Hu, Yan Dai, Ahad Ollah Ezzati, Junghoon Lee, Jie Deng, Xun Jia

Abstract read
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoyu HuDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Yan DaiDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ahad Ollah EzzatiDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Junghoon LeeDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Jie DengDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Xun JiaDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

Next generation small animal radiation research platformR37CA214639 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI JIA, XUN · 2018 to 2024
$3.8M
Adversarially Based Virtual CT Workflow for Evaluation of AI in Medical ImagingR01EB032716 · NIBIB · RENSSELAER POLYTECHNIC INSTITUTE · PI JIA, XUN, MUELLER, KLAUS · 2022 to 2025
$2.5M
Precise image guidance for liver cancer stereotactic body radiotherapy using element-resolved motion-compensated cone beam CTR01CA227289 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI JIA, XUN · 2018 to 2022
$2.0M
NCI NIH HHS R01 CA227289NCI NIH HHS R37 CA214639NIBIB NIH HHS R01 EB032716NIH HHS R01CA227289NIH HHS R01EB032716NIH HHS R37CA214639
6 · The paper itself

Abstract

purposeThe 2024 quantitative intra-voxel incoherent motion diffusion MRI (IVIM-dMRI) reconstruction grand challenge aimed to benchmark and advance reconstruction algorithms for extracting quantitative tissue parameters from diffusion MRI (dMRI) data. Focusing on the IVIM model, the challenge aimed to improve the accuracy and robustness of clinical parameter estimation, addressing key barriers to broader clinical adoption.

methodsParticipants were tasked with reconstructing fractional perfusion, pseudo-diffusion coefficient, and true diffusion coefficient from simulated

resultsThe challenge attracted 42 teams from six countries, with seven progressing to the final phase. The rRMSE ranged in [0.0345, 1.24]. The top-performing algorithm employed a cascaded U-Net architecture for image denoising and parameter fitting. Overall, the competition highlighted the potential of advanced methodologies, particularly DL, in addressing complex inverse problems in medical imaging.

conclusionThe IVIM-dMRI grand challenge demonstrated significant advancements in the accuracy and robustness of dMRI reconstruction. Although the simulation-based approach provided a controlled environment, future efforts must address real-world complexities to ensure clinical applicability.

Indexed as

Diffusion Magnetic Resonance ImagingImage Processing, Computer-AssistedAlgorithmsDeep LearningHumansMotionPhantoms, Imagingdeep learningdiffusion MRIimage reconstruction

Identifiers

PMID40665555
PMCPMC12639196

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.