Evidence map›Paper›PMID 40665448›Full record

ArticleJournal of cheminformatics2025

Structure-based machine learning screening identifies natural product candidates as potential geroprotectors.

Jose Alberto Santiago-de-la-Cruz, Nadia Alejandra Rivero-Segura, Juan Carlos Gomez-Verjan

Abstract read
In one paragraph

Article in Journal of cheminformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jose Alberto Santiago-de-la-CruzDirección de Investigación, Instituto Nacional de Geriatría, Mexico City, 10200, México.
Nadia Alejandra Rivero-SeguraDirección de Investigación, Instituto Nacional de Geriatría, Mexico City, 10200, México.
Juan Carlos Gomez-VerjanDirección de Investigación, Instituto Nacional de Geriatría, Mexico City, 10200, México. jverjan@inger.gob.mx.

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías 319706
6 · The paper itself

Abstract

Age-related diseases and syndromes result in poor quality of life and adverse outcomes, representing a challenge to healthcare systems worldwide. Several pharmacological interventions have been proposed to target the aging process to slow its adverse effects. The so-called geroprotectors have been proposed as novel molecules that could maintain the organism's homeostasis, targeting specific aspects linked to the hallmarks of aging and delaying the adverse outcomes associated with age. On the other hand, machine learning (ML) is revolutionising drug design by making the process faster, cheaper, and more efficient.

Indexed as

Age-related diseasesAgingCheminformaticsDrug developmentGeroprotectorsMachine learningNatural products

Identifiers

PMID40665448
PMCPMC12265111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.