Trial reportAlzheimer's research & therapy2025
Cardiovascular risk factors are associated with lower posterior-medial network functional connectivity in older adults.
Trial report in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02977819 (Interventional Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training and Foreign Language Learning on Behavioral, Biological and Neuroimaging Measures), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interventional Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training and Foreign Language Learning on Behavioral, Biological and Neuroimaging Measures
Who cites it
1 citing paper in PubMed.
- Lipid Metabolism Reprogramming in the Aging Brain: Glial-Mediated Pathogenic Mechanisms and Translational Strategies in Neurodegeneration.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundCortico-hippocampal functional networks, specifically the anterior-temporal (AT) and posterior-medial (PM) systems, are crucial for memory and highly vulnerable to aging and Alzheimer's disease (AD). While modifiable cardiovascular risk factors may offer prevention opportunities to preserve brain aging, their effects on AT/PM functional connectivity remain unknown. This study aims to investigate these associations in older adults, considering major risk categories and exploring potential interactions with protective lifestyle habits and AD risk factors.
methodsOne hundred thirty-one community-dwelling cognitively unimpaired adults aged 65 + were selected from the Age-Well trial, a French monocentric population-based study conducted from 2016 to 2020. Resting-state fMRI and cardiovascular risk assessments were performed at baseline and 18-month follow-up. Functional connectivity within the AT and PM networks was derived from seed-based analyses using the perirhinal and parahippocampal cortices as individual seeds, respectively. Generalized additive and linear mixed models assessed the effects of cardiovascular risk factors on AT/PM functional connectivity, including interactions with protective lifestyle habits and AD risk factors.
resultsBaseline mean age was 69 (65-84) years, with 63.5% women. Higher abdominal fat (95% CI: -0.00118, -0.00005; F = 5.39; P =.02), higher LDL cholesterol (95% CI: -0.01642, -0.00345; F = 10.40; P =.001), longer smoking duration (95% CI: NA; F = 3.89; P =.03) and greater alcohol consumption (95% CI: -0.01134, -0.00045; F = 4.66; P =.02) were consistently associated with lower PM connectivity, collectively explaining 11.4% of the variance. However, only LDL cholesterol survived multiple comparisons, possibly reflecting a more direct involvement in cardiovascular mechanisms affecting functional connectivity. No association was found with AT connectivity. Exploratory analyses showed that these relationships were independent of cerebral Aβ-positivity or APOE-ε4 carrier status and were unaffected by physical activity and Mediterranean diet when considered separately. DISCUSSION: This study highlights converging associations between higher cardiovascular risk factors and lower functional connectivity in cognitively unimpaired older adults, specifically affecting the PM-but not AT-network, and independent of AD risk. Targeting these specific modifiable factors may prevent age-related network alterations to promote cognitive health in aging. TRIAL REGISTRATION INFORMATION: The Age-Well trial was registered with ClinicalTrials.gov on November 25, 2016 (identifier: NCT02977819).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.