SynthesisJournal of orthopaedic surgery and research2025
MicroRNAs in the diagnosis of osteoarthritis: a systematic review and meta-analysis of observational studies.
Synthesis in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- MiR-21 promotes osteogenic transformation in ankylosing spondylitis fibroblasts and modulates bone metabolism in a murine arthritis model potentially involving the MAPK NF-κB pathway.Journal of orthopaedic surgery and research · 2026Article
- miR-584-5p alleviates osteoarthritis by targeting HIF1A to regulate chondrocyte function and extracellular matrix metabolism.Journal of orthopaedic surgery and research · 2026Article
- Dysregulation of exosomal miRNAs in A2 astrocytes under oxygen-glucose deprivation is associated with neuronal pyroptosis: a role for miR-139-5p in targeting NLRP3.Journal of orthopaedic surgery and research · 2026Article
- miR-29a-3p targets the PI3K/Akt signaling pathway to suppress inflammation and MMP-9-dependent matrix degradation in spinal tuberculosis.Journal of orthopaedic surgery and research · 2026Article
- The clinical role of lncRNA PRKG1-AS1 in lumbar disc degeneration and its mechanism in regulating inflammation and ferroptosis via miR-218-5p.Journal of orthopaedic surgery and research · 2026Article
- miR-211-5p/FOXO3 axis accelerates osteogenic differentiation and fracture healing by mediating Wnt/β-catenin pathway.Journal of orthopaedic surgery and research · 2026Article
- Long non-coding RNA CKMT2-AS1 serves as a biomarker for osteoarthritis and participates in chondrocyte injury via miR-6720-5p.Journal of orthopaedic surgery and research · 2026Article
- Dexmedetomidine mitigates postoperative delirium after hip fracture surgery in elderly patients by modulating miR-107 expression.Journal of orthopaedic surgery and research · 2026Article
- LncRNA GAS5 inhibits the remodeling of the tumor microenvironment by binding to miR-93-5p, thereby suppressing the development of osteosarcoma.Journal of orthopaedic surgery and research · 2026Article
- The role and mechanism of miR-875-3p in targeting SLC39A14 to regulate ferroptosis in osteosarcoma proliferation, migration, and invasion.Journal of orthopaedic surgery and research · 2026Article
- Inhibition of miR-224-5p promotes osteogenesis in dental pulp stem cells by targeting the PTEN/PI3K/AKT axis.Journal of orthopaedic surgery and research · 2026Article
- circ_0044235 exacerbates neuroinflammation and apoptosis following spinal cord injury by targeting miR-338-5p.Journal of orthopaedic surgery and research · 2026Article
- Clinical significance and regulatory mechanism of miR-4284 in lumbar intervertebral disc degeneration.Journal of orthopaedic surgery and research · 2026Article
- Long non-coding RNA LINC-PINT: emerging clinical significance and molecular mechanisms in knee osteoarthritis.Journal of orthopaedic surgery and research · 2026Article
- piR-27222 alleviates dexamethasone-induced osteoporosis by inhibiting ferroptosis through modulating WWP1.Journal of orthopaedic surgery and research · 2026Article
- The expression characteristics of miR-206-3p in musculoskeletal tissue and its clinical significance.Journal of orthopaedic surgery and research · 2026Article
- miR-1290 serves as a potential biomarker for osteoporotic fracture and regulates osteoblast function by targeting KDM5A.Journal of orthopaedic surgery and research · 2026Article
- Mesenchymal stem cell-derived miR-125b-1-3p-abundant exosomes alleviate osteoarthritis by modulating the KDM6B-H3K27me3-FOXM1 axis.Journal of orthopaedic surgery and research · 2026Article
- FENDRR-mediated regulation of osteoclast differentiation through the miRNA-129-5p/P2X7R axis.Journal of orthopaedic surgery and research · 2026Article
- LINC00312 affects the progression of osteoarthritis by targeting miR-331-3p/DUSP5 axis.Journal of orthopaedic surgery and research · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, the diagnostic and prognostic values of microRNAs (miRNAs) in different diseases have been extensively studied. Therefore, a meta-analysis of miRNAs has been performed to unravel whether miRNAs could be novel diagnostic markers for osteoarthritis (OA).
methodsIn this meta-analysis, Cochrane, EMBASE, Web of Science, and PubMed were systematically searched for relevant studies on "miRNA" and "OA". Studies were selected based on pre-defined criteria. Bivariate models were utilized to analyze diagnostic parameters such as summarized diagnostic odds ratio, positive likelihood ratio, negative likelihood ratio, sensitivity, specificity, and area under the summary receiver operating characteristic curve (AUC). Parameters were provided with their corresponding 95% confidence interval (CI). Additionally, the main sources of heterogeneity were probed by conducting subgroup and sensitivity analyses.
resultsA total of 31 studies from 14 articles were included based on the exclusion and inclusion criteria, encompassing 26 miRNAs and 1842 subjects in total. The pooled estimates unraveled that miRNAs displayed a high diagnostic accuracy, with an overall sensitivity of 0.81 (95% CI, 0.77-0.85) and specificity of 0.85 (95% CI, 0.81-0.88) for diagnosing OA. The overall AUC was 0.90 (95% CI, 0.87-0.92). The subgroup analysis revealed that miRNAs exhibited higher diagnostic efficacy in downregulated genes compared to upregulated genes. miRNAs demonstrated higher diagnostic value in Asian populations than in European populations.
conclusionmiRNAs are promising non-invasive biomarkers for the diagnosis of OA with high accuracy. To establish consistency in international diagnostic standards and address the limitations of traditional diagnostic methods, further research is required for validation.
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