Evidence map›Paper›PMID 40665250›Full record

ArticleBMC gastroenterology2025

Impacts of salt restriction on nutritional status, sarcopenia, and mortality of cirrhotic patients with ascites.

Maha Elsabaawy, Mohammed Ragab, Madiha Naguib, Eman Kamal, Maymona Al-Khalifa, Khaled Gamil, Marwa Elfayoumy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maha ElsabaawyHepatology and Gastroenterology Department, National Liver Institute Minufiya University, Shebeen Elkoom, Egypt. maha.ahmed@liver.menofia.edu.eg.ORCID http://orcid.org/0000-0002-3110-1547
Mohammed RagabHepatology and Gastroenterology Department, National Liver Institute Minufiya University, Shebeen Elkoom, Egypt.
Madiha NaguibHepatology and Gastroenterology Department, National Liver Institute Minufiya University, Shebeen Elkoom, Egypt.
Eman KamalAnesthesia and Intensive Care Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt.
Maymona Al-KhalifaTherapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt.
Khaled GamilHepatology and Gastroenterology Department, National Liver Institute Minufiya University, Shebeen Elkoom, Egypt.
Marwa ElfayoumyHepatology and Gastroenterology Department, National Liver Institute Minufiya University, Shebeen Elkoom, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalt restriction is a cornerstone in managing ascites in cirrhotic patients; however, its impact on nutritional status, sarcopenia, and mortality remains unclear.

aimTo evaluate the effects of a salt-restricted diet (SRD) on ascites control, body composition, sarcopenia development, and patient survival in cirrhotic patients with decompensated liver disease.

methodsThis prospective study included 102 patients with grade III ascites, categorized into two groups based on dietary adherence: Salt-Restricted Diet (SRD), (n = 46) and Salt-Unrestricted Diet (SUD) (n = 56). Sodium intake was assessed using the Dietary Sodium Restriction Questionnaire (DSRQ) and spot urine Na/K ratio. Nutritional status, sarcopenia, ascites control, and six-month mortality were evaluated.

resultsThe SRD group showed better ascites control, with fewer paracentesis sessions per month (1.57 ± 0.65 vs. 4.07 ± 1.43, p < 0.001). Sarcopenia was more prevalent in the SRD group (p < 0.001), with lower SMI (4.88 ± 7.13 vs. 16.7 ± 544.8, p < 0.001) and TR PMM (19.03 ± 3.68 vs. 71.92 ± 191.9, p < 0.001). Higher nutritional risk was significantly associated with SRD (p = 0.001). Mortality was significantly higher in the SRD group (67.4%) compared to the SUD group (35.7%), p = 0.001. Multivariate analysis identified sarcopenia (OR = 2.684, p = 0.006) and SRD (OR = 1.65, p < 0.001) as independent predictors of mortality.

conclusionWhile effective in ascites control, sodium restriction may compromise nutritional status, heighten sarcopenia risk, and increase mortality, highlighting the need for a more individualized dietary approach.

Indexed as

AscitesDiet, Sodium-RestrictedLiver CirrhosisNutritional StatusSarcopeniaAgedBody CompositionFemaleHumansMaleMiddle AgedProspective StudiesSodiumSodiumAscitesCirrhosisMalnutritionNutritional statusSalt restrictionSodium intake

Identifiers

PMID40665250
PMCPMC12261796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.