Evidence map›Paper›PMID 40665135›Full record

ArticleScientific reports2025

Transfusion ratios and survival in severe blunt trauma patients receiving massive transfusion.

Toru Takiguchi, Tomohisa Seki, Takashi Tagami, Yu Akagi, Ryuta Nakae, Hiromasa Ito, Yoshimasa Kawazoe, Ichiro Okada, Shiei Kim, Masaaki Inoue and 2 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

12 authors.

Toru TakiguchiDepartment of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan. toru-takiguchi@nms.ac.jp.
Tomohisa SekiDepartment of Healthcare Information Management, The University of Tokyo Hospital, Tokyo, Japan.
Takashi TagamiDepartment of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Yu AkagiDepartment of Biomedical Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ryuta NakaeDepartment of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Hiromasa ItoDepartment of Healthcare Information Management, The University of Tokyo Hospital, Tokyo, Japan.
Yoshimasa KawazoeDepartment of Healthcare Information Management, The University of Tokyo Hospital, Tokyo, Japan.
Ichiro OkadaDepartment of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Shiei KimDepartment of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Masaaki InoueDepartment of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Kazuhiko OheDepartment of Healthcare Information Management, The University of Tokyo Hospital, Tokyo, Japan.
Shoji YokoboriDepartment of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optimal transfusion ratios for severe blunt trauma requiring massive transfusion remain unclear. This nationwide retrospective cohort study used data from the Japan Trauma Data Bank (2019-2022) and included patients receiving ≥ 10 units of packed red blood cells (pRBC) within 24 h. The fresh frozen plasma (FFP)-to-pRBC and platelet concentrate (PC)-to-pRBC ratios were categorized as 0-0.5, 0.5-1, 1-1.5, 1.5-2, and > 2. Among 2,849 eligible patients, an FFP-to-pRBC ratio of 1-1.5 was associated with significantly higher in-hospital survival than 0.5-1 (adjusted odds ratio [OR], 1.46; 95% confidence interval [CI], 1.12-1.92; P = 0.006). A PC-to-pRBC ratio of 1.5-2 also showed a trend toward improved survival (1.62; 1.00-2.69; P = 0.053). Patients were categorized into three phenotypes: truncal trauma with shock (70.3%), moderate head and extremity trauma (11.8%), and severe head trauma with consciousness disturbances (17.9%). In the truncal trauma with shock phenotype, FFP-to-pRBC ratios of 1-1.5 (1.56; 1.12-2.20; P = 0.010) and > 2 (2.32; 1.14-5.10; P = 0.027) were associated with improved survival. Higher FFP-to-pRBC and PC-to-pRBC ratios may be associated with improved survival, especially in truncal trauma with shock.

Indexed as

Blood TransfusionWounds, NonpenetratingAdultAgedFemaleHospital MortalityHumansJapanMaleMiddle AgedPlasmaRetrospective StudiesBlunt traumaClusteringMassive transfusionShockTransfusion ratioTruncal trauma

Identifiers

PMID40665135
PMCPMC12263878

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