ArticleScientific reports2025
Reassessing lidocaine as an electroporation sensitizer in vitro.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Invasive properties of patient-derived glioblastoma cells after reversible electroporationRadiology and oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
High-intensity pulsed electric fields induce transient increase in membrane permeability, a phenomenon known as electroporation, with broad applications in medicine, including electrochemotherapy (ECT), gene electrotransfer and tissue ablation. As electroporation technologies become increasingly established in clinical practice, understanding how commonly used pharmacological agents influence treatment outcomes is gaining importance. Lidocaine, a widely used local anesthetic and ion channel modulator, has recently been investigated as a potential sensitizer to enhance the efficacy of electroporation. Here, we examined the effects of lidocaine on membrane permeabilization and cell viability using standard 8 × 100 µs ECT pulses across four cell lines: melanoma B16-F1, myoblast C2C12, CHO-K1 cells with low ion channel expression, and NS-HEK cells with stable Na
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.