Design, synthesis and evaluation of benzodioxole and bromofuran tethered 1,2,4-triazole hybrids as potential anti breast cancer agents with computational insights.

Manjunath R, Sushruta S Hakkimane, Shashikala B S, Santhosh L Gaonkar

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Manjunath RDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Sushruta S HakkimaneDepartment of Biotechnology, Manipal Institute of Technology Bengaluru, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Shashikala B SDepartment of Physics, Sri Jayachamarajendra College of Engineering, JSS Technical Institutions Campus, JSS Science and Technology University, Mysuru, Karnataka, 570006, India.

Santhosh L GaonkarDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. sl.gaonkar@manipal.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,2,4-Triazole derivatives are the focus of extensive research in medicinal chemistry because of their diverse biological activities, particularly their potential as anticancer agents. In this study, we designed and synthesized six compounds featuring benzo[d][1,3]dioxole and 5-bromofuran tethered to 1,2,4-triazole hybrids. This was achieved through an efficient four-step protocol with reproducible results. The characterization of the 1,2,4-triazoles was conducted via various analytical techniques, including FTIR,

Indexed as

Antineoplastic AgentsBreast NeoplasmsDrug DesignFuransTriazolesDrug Screening Assays, AntitumorFemaleHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity Relationship1,2,4-triazoleAntineoplastic AgentsFuransTriazoles1,2,4-Triazoles3,4-(Methylenedioxy) phenylacetic acid5-BromofuranBenzo[d] [1,3] dioxoleDFTJorgensen’s rule of threeLipinski’s rule of fiveMEP

Identifiers

PMID40665119

DOI10.1038/s41598-025-09420-1

PMCPMC12263850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.