ArticleReproductive sciences (Thousand Oaks, Calif.)2025
Peptidomic and Proteomic Signatures in Human Blood Serum, Follicular Fluid and Spent Media: A Study of Embryo Development Competency after In Vitro Fertilization.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Non-invasive biomarkers in assisted reproductive technologies, current evidence, clinical utility and future perspectives.Frontiers in reproductive health · 2026Review
- Decoding the Follicular Fluid Microenvironment: Integrative Biomarkers and Multiomics Signatures to Predict IVF Outcomes.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This research aimed to investigate peptide barcodes and proteomic profiles in blood serum, follicular fluid, and spent media from infertile patients, focusing on their potential to retrieve good-quality embryo during in vitro fertilization (IVF). Biological samples were collected from 30 participants, equally comprising individuals who retrieved mature oocyte and developed or did not develop to good-quality blastocyst. Analysis of peptide barcodes and proteomic profiles was conducted using MALDI-TOF MS and nano-LC-ESI MS/MS. Subsequently, data peptide mass peak patterns, proteins and protein interaction networks were generated. Primary results in participants with good embryo development competency indicated that 448 of 1,792 peptide mass peaks were up-regulated in blood serum, 76 of 1,793 peptides in follicular fluid, and 51 of 1,610 peptides in spent media (fold-change ≥ 1.0, P < 0.05). Up-regulated proteins including angiomotin in blood serum, capping protein and janus kinase in follicular fluid were identified (edge confidence scores > 0.90). Additionally, spent media showed unique protein network involving ATP-dependent RNA helicase DDX19A and ankyrin repeat proteins via ubiquitin C protein (edge confidence score > 0.80). In conclusion, identified peptide barcodes and protein interaction networks in this study may offer novel insights into molecular mechanisms underlying embryo development competency after IVF treatment.
Indexed as
Identifiers
40665108What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.