ArticleScientific reports2025
The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head irradiation is a common treatment for brain cancer; however, it can cause side effects in healthy brain tissue. This study aimed to test whether citicoline administration modulates radiation-induced brain mitochondrial dysfunction in rats. The head of the animal was exposed to 10 Gy γ-radiation. Citicoline (300 mg/kg body weight/day) was administered intraperitoneally for four weeks after irradiation. Some biochemical changes related to mitochondrial function in brain tissue were studied. The results showed that citicoline administration after head irradiation reduced oxidative stress, enhanced the activity of mitochondrial complexes (I and II), increased the aconitase enzyme activity, boosted ATP production, and restored the levels of calcium, iron, and caspase-3, compared to the corresponding values in irradiated rats. The levels of glucose and cholesterol in brain tissue were modulated. Citicoline also increased acetylcholine level and alpha-7 nicotinic receptor mRNA expression and decreased acetylcholinesterase activity in the brain tissue of irradiated-treated rats. We concluded that citicoline could attenuate the harmful effects of γ-radiation on the brain by modulating mitochondrial function, neurotransmission, and calcium & iron homeostasis, thus suppressing the mitochondrial-mediated apoptosis pathway. However, additional studies are required to validate and confirm these results before any clinical application can be recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.