Evidence map›Paper›PMID 40665051›Full record

ArticleNature medicine2025

Large-scale proteomics project seeks cures for neurodegenerative diseases.

Boris Decourt, Marwan N Sabbagh, Michelle M Mielke

Abstract read
In one paragraph

Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Boris DecourtTexas Tech University Health Sciences Center, School of Medicine, Department of Pharmacology and Neuroscience, Lubbock, TX, USA. bdecourt@ttuhsc.edu.ORCID http://orcid.org/0000-0001-7637-5034
Marwan N SabbaghAlzheimer's and Memory Disorders Division, Barrow Neurological Institute, Phoenix, AZ, USA.
Michelle M MielkeDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-7177-1185

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
Alzheimer Diagnosis in older Adults with Chronic Conditions ADACC NetworkU24AG082930 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Nicole R. Fowler, Thomas K Karikari · 2023 to 2026
$7.3M
Sex-specific risk factors and trajectories of blood biomarkers for Alzheimer's disease and related dementiasRF1AG079397 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MIELKE, MICHELLE M, MURRAY, ANNE M · 2022 to 2024
$4.5M
MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI PatientsR01AG059008 · NIA · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI DECOURT, BORIS, SABBAGH, MARWAN NOEL · 2018 to 2023
$3.6M
Stress, Weathering, and Blood-Based Biomarkers of Alzheimer’s Disease: A Longitudinal Study of Low Income, Aging African AmericansRF1AG077386 · NIA · UNIVERSITY OF GEORGIA · PI MIELKE, MICHELLE M, SIMONS, RONALD L · 2022 to 2023
$3.2M
Repurposing Siponimod for Alzheimer's DiseaseR01AG073212 · NIA · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI Boris Decourt, MARWAN Noel SABBAGH · 2021 to 2026
$2.8M
"What is N?" Towards operationalizing neurodegeneration in Alzheimer's and related dementiasRF1AG069052 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, MIELKE, MICHELLE M · 2021 to 2021
$2.4M
NIA NIH HHS P30 AG019610NIA NIH HHS R01 AG059008NIA NIH HHS R01 AG073212NIA NIH HHS RF1 AG069052NIA NIH HHS RF1 AG077386NIA NIH HHS RF1 AG079397NIA NIH HHS U24 AG082930
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40665051
PMCPMC12950189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.