Evidence map›Paper›PMID 40665014›Full record

ArticleBritish journal of cancer2025

Fatigue in long-term cancer survivors: prevalence, associated factors, and mortality. A prospective population-based study.

Melissa S Y Thong, Daniela Doege, Lena Koch-Gallenkamp, Heike Bertram, Andrea Eberle, Bernd Holleczek, Alice Nennecke, Annika Waldmann, Sylke Ruth Zeissig, Ron Pritzkuleit and 3 more

Abstract read
In one paragraph

Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Article
  6. Adherence to 24-hour movement guidelines and mortality risks in US cancer survivors: a national cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Melissa S Y ThongCancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.thong@dkfz.de.ORCID http://orcid.org/0000-0002-6987-705X
Daniela DoegeCancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7499-5376
Lena Koch-GallenkampDivision of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7290-906X
Heike BertramCancer Registry of North Rhine-Westphalia, Bochum, Germany.
Andrea EberleBremen Cancer Registry, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.ORCID http://orcid.org/0000-0003-4195-5236
Bernd HolleczekSaarland Cancer Registry, Saarbrücken, Germany.ORCID http://orcid.org/0000-0001-8759-4371
Alice NenneckeHamburg Cancer Registry, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7115-5160
Annika WaldmannInstitute for Social Medicine and Epidemiology, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-5909-9936
Sylke Ruth ZeissigInstitute of Clinical Epidemiology and Biometry (ICE-B), Julius Maximilian University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-0743-6128
Ron PritzkuleitCancer Registry of Schleswig-Holstein, Lübeck, Germany.ORCID http://orcid.org/0000-0002-2858-2941
Elmar BrählerDepartment of Medical Psychology and Medical Sociology, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-2648-2728
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6129-1572
Volker ArndtCancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9320-8684

Funding

Deutsche Krebshilfe (German Cancer Aid) 108262, 70112089
6 · The paper itself

Abstract

backgroundWe compared fatigue severity in breast, prostate or colorectal cancer survivors 5-16 years post-diagnosis with cancer-free controls, and examined factors associated with fatigue and its association with all-cause mortality in survivors.

methodsParticipants of the CAncEr Survivorship - A multi-Regional (CAESAR) study completed the Fatigue Assessment Questionnaire (FAQ) between 2009 and 2011. The FAQ assesses affective, cognitive, and physical fatigue, and sleep problems. We derived the odds of fatigue using logistic regression with the 75

resultsThe sample comprised 6057 survivors, of whom approximately one-third reported affective, cognitive, or physical fatigue. Demographic (age, relationship), clinical (chemotherapy), comorbidity (depression), lifestyle, and psychological factors were associated with higher odds of fatigue symptoms and total fatigue. Fatigue symptoms, predominantly physical fatigue, were strongly associated with mortality (unadjusted hazard ratios (HRs) ranged from 1.48 to 2.40). The HRs were attenuated after adjustment for comorbidities and depressive symptoms, although affective and physical fatigue remained independent risk factors for mortality.

conclusionsDemographic, clinical, comorbidity, lifestyle, and psychological factors were associated with fatigue in long-term survivors. Fatigued survivors have a higher mortality risk. Lowering the burden of fatigue by a comprehensive approach might result in better survival.

Indexed as

Cancer SurvivorsFatigueNeoplasmsAdultAgedBreast NeoplasmsColorectal NeoplasmsFemaleHumansMaleMiddle AgedPrevalenceProspective StudiesRisk FactorsSurveys and Questionnaires

Identifiers

PMID40665014
PMCPMC12449452

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.