ArticleScientific reports2025
Protective role of nigella sativa oil and vitamins C and E against aflatoxin M
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Role of GRP78/ATF6/IRE1 and Caspase-12 Signaling Pathways in the Protective Effects of n-Hexane Oil Extract of Black Soldier Flies' Larvae (Iranian journal of pharmaceutical research : IJPRArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explores the protective efficacy of Nigella sativa oil (NSO), Vitamin C, and E in countering the toxic effects of Aflatoxin M1 (AFM1) in neonatal Wistar rats. A total of 117 neonatal rats were randomized into 13 groups (A-M) and observed over 12 weeks. Group A served as the control, while the remaining groups were exposed to varying concentrations of AFM1, either alone or in combination with the supplements. Hematological parameters, including Packed Cell Volume (PCV), Red Blood Cells (RBC), Hemoglobin (HB), White Blood Cells (WBC), and liver enzyme activities, were measured using Microhematocrit Reader, Hemocytometer, Hemoglobinometer, and Spectrophotometer respectively. Histopathological assessments of liver tissues were conducted using staining techniques to assess cellular damage, inflammation, and fibrosis. The results demonstrated that simultaneous supplementation with NSO, Vitamin C, and E significantly improved PCV, HB, and RBC levels while reducing WBC counts and liver enzyme activities in comparison to AFM1-exposed groups. Notably, NSO effectively restored hematological parameters and facilitated liver tissue regeneration, even at higher concentrations of AFM1. In contrast, Vitamins C and E displayed protective effects predominantly at lower toxin levels. These findings suggest that NSO, in conjunction with Vitamin C and E, plays a pivotal role in mitigating the detrimental effects of AFM1 toxicity. NSO shows superior potential in reversing blood dyscrasia and liver damage. The study highlights the promising therapeutic utility of Nigella sativa oil as a natural remedy for alleviating aflatoxin-induced oxidative stress and organ damage, reinforcing its potential to safeguard public health against aflatoxin exposure.
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