ArticleNature neuroscience2025
Mapping human thalamocortical connectivity with electrical stimulation and recording.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Neural integrator and orchestrator communities shape spontaneous signaling in the human brain.PNAS nexus · 2026Article
- Causal Mapping of Bodily Awareness and Mesoscale Circuit Organization in the Human Cingulate and Precuneus.Research square · 2026Article
- Thalamocortical orchestration of human theory of mind.bioRxiv : the preprint server for biology · 2026Article
- Stimulation-evoked orbitofrontal activity as a biomarker for DBS personalization in depression.medRxiv : the preprint server for health sciences · 2026Article
- How Thalamo-Cortical Loops Modulate Cortico-Cortical Evoked Potentials?Brain topography · 2026Article
- Conserved fiber topography of the anterior limb of the internal capsule in treatment-resistant psychiatric patients.bioRxiv : the preprint server for biology · 2026Article
- Parallel processing chains span cytoarchitectures to organize association cortex.bioRxiv : the preprint server for biology · 2026Article
- Advances in Thalamic Neuromodulation for Epilepsy: From Mechanisms to Clinical Translation.Epilepsy currents · 2026Article
- Functional Architecture of the Human Insula Revealed by Causal Intracranial Mapping.Research square · 2026Article
- Neural integrator and orchestrator communities shape spontaneous signaling in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Electrophysiological connections linking medial pulvinar, anterior nuclei of the thalamus and the hippocampus.Brain : a journal of neurology · 2025Article
- Thalamic stereoelectroencephalography: safety, accuracy, and thalamocortical connectivity.medRxiv : the preprint server for health sciences · 2025Article
- Short-Term Modulation of Epileptic Network with Low-Frequency Thalamic Stimulation.medRxiv : the preprint server for health sciences · 2025Article
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5 authors.
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Abstract
The brain's functional architecture is shaped by electrophysiological interactions between its components, encompassing both cortical and subcortical structures. In this study, we provide an atlas of electrophysiological causal connections across 4,864 brain sites in 27 human participants using repeated single-pulse electrical stimulations and recordings with intracranial electrodes implanted in cortical regions and multiple thalamic nuclei. We show distinct spectral signatures elicited by perturbations of specific brain areas. Identified features of causal connectivity exhibited highly organized yet distinct patterns, indicating that each feature may correspond to a separate mode of information transmission across brain regions. Notably, we report a new waveform with unique temporal and spatial characteristics specifically linked to thalamic stimulations, namely delayed-onset theta oscillations in both ipsilateral and contralateral cortical regions. These findings contribute to a more detailed understanding of the human brain's functional architecture and offer valuable data for the development of biologically informed computational models.
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