Efficacy of urolithin B-Loaded mesoporous silica nanoparticles modified with graphene quantum Dots against MCF-7 breast Cancer cells.

Bahareh Nezhadhossein, Akbar Safipour Afshar, Masoud Homayouni Tabrizi, Fatemeh Saeid Nematpour, Mahnaz Mohtashami

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Bahareh NezhadhosseinDepartment of Biology, Ne.C., Islamic Azad University, Neyshabur, Iran.

Akbar Safipour AfsharDepartment of Biology, Ne.C., Islamic Azad University, Neyshabur, Iran. asafshar@iau.ac.ir.

Masoud Homayouni TabriziDepartment of Biology, Ma.C., Islamic Azad University, Mashhad, Iran. mhomayouni6@iau.ac.ir.

Fatemeh Saeid NematpourDepartment of Biology, Ne.C., Islamic Azad University, Neyshabur, Iran.

Mahnaz MohtashamiDepartment of Biology, Ne.C., Islamic Azad University, Neyshabur, Iran.

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6 · The paper itself

Abstract

This study investigated the anti-cancer effects of GQD@MSN-Uro-B nanoparticles (NPs) on the MCF7 cancer cell line, focusing on their antioxidant properties. GQD@MSN-Uro-B was synthesized by first preparing graphene quantum dots (GQDs) from graphene oxide (GO) through a hydrothermal method, followed by the sol-gel synthesis of mesoporous silica nanoparticles (MSNs). The GQDs were then covalently bonded to the MSNs, and Uro-B was loaded onto the resulting nanocarriers. Characterization using DLS revealed that GQD@MSN-Uro-B exhibited a Z-average particle size of 223.75 nm and a zeta potential of - 22.59 mV, indicating good stability compared to MSN-Uro-B@GQD, which had a larger Z-average size of 241.02 nm and a zeta potential of - 14.99 mV. The NPs demonstrated significant cytotoxicity with an IC

Indexed as

Antineoplastic AgentsBreast NeoplasmsCoumarinsGraphiteNanoparticlesQuantum DotsSilicon DioxideAntioxidantsApoptosisCell SurvivalFemaleHumansMCF-7 CellsParticle SizePorosityAntineoplastic AgentsAntioxidantsCoumarinsGraphiteSilicon DioxideAntioxidantCancerCytotoxicityGraphene quantum DotsMesoporous silica nanoparticlesUrolithin B

Identifiers

PMID40664936

DOI10.1038/s41598-025-10904-3

PMCPMC12264002

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