Evidence map›Paper›PMID 40664913›Full record

ArticleGene therapy2025

Saqlain Suleman, Sharmin Alhaque, Andrew Guo, Huairen Zhang, Annette Payne, Marco Zahn, Serena Fawaz, Mohammad S Khalifa, Susan Jobling, David Hay and 11 more

Abstract read
In one paragraph

Article in Gene therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Saqlain SulemanDepartment of Life Sciences, College of Health, Medicine & Life Sciences, Brunel University of London, Uxbridge, UK.
Sharmin AlhaqueDepartment of Life Sciences, College of Health, Medicine & Life Sciences, Brunel University of London, Uxbridge, UK.
Andrew GuoBiomavericks, London, UK.
Huairen ZhangBiomavericks, London, UK.
Annette PayneDepartment of Computer Science, College of Engineering Design and Physical Sciences, Brunel University of London, Uxbridge, UK.ORCID 0000-0002-2009-0141
Marco ZahnGenewerk GmbH, Heidelberg, Germany.
Serena FawazDepartment of Life Sciences, College of Health, Medicine & Life Sciences, Brunel University of London, Uxbridge, UK.
Mohammad S KhalifaDepartment of Life Sciences, College of Health, Medicine & Life Sciences, Brunel University of London, Uxbridge, UK.
Susan JoblingTestAVec Ltd, Queensgate House, Maidenhead, UK.
David HayCentre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK.
Matteo FrancoGenewerk GmbH, Heidelberg, Germany.ORCID 0000-0002-1267-4083
Raffaele FronzaGenewerk GmbH, Heidelberg, Germany.
Wei WangGenewerk GmbH, Heidelberg, Germany.
Olga Strobel-FreidekindGenewerk GmbH, Heidelberg, Germany.
Annette DeichmannGenewerk GmbH, Heidelberg, Germany.
Yasuhiro TakeuchiDivision of Infection and Immunity, University College London, London, UK.
Irene Gil-FarinaGenewerk GmbH, Heidelberg, Germany.
Jan KlapwijkCornelis Consulting Ltd., Hertfordshire, UK.
Stefany PereraDepartment of Life Sciences, College of Health, Medicine & Life Sciences, Brunel University of London, Uxbridge, UK.
Manfred SchmidtDepartment of Computer Science, College of Engineering Design and Physical Sciences, Brunel University of London, Uxbridge, UK.
Michael ThemisDepartment of Life Sciences, College of Health, Medicine & Life Sciences, Brunel University of London, Uxbridge, UK. michael.themis@brunel.ac.uk.ORCID 0000-0002-6719-4271

Funding

National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs) andrewguo@biomavericks.comNational Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs) CRACK IT Challenge 21: InMutagene awardNational Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs) NC3Rs CRACK IT Challenge 21: InMutagene award
6 · The paper itself

Abstract

Lentivirus vectors are effective for treatment of genetic disease. However, safety associated with vector related genotoxicity is of concern and currently available models are not reliably predictive of safety in humans. We have developed

Indexed as

Genetic VectorsLentivirusDNA DamageGenetic TherapyHumansInduced Pluripotent Stem CellsPromoter Regions, Genetic

Identifiers

PMID40664913
PMCPMC12714580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.