ArticleNature aging2025
Disease burden, lifetime healthcare cost and long-term intervention impact projections among older adults in Singapore.
Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Possible osteosarcopenia is associated with loss in intrinsic capacity and early cognitive deficits: a longitudinal study of older adults in Singapore.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Implementation outcomes from delivering 'acute-on-demand telehealth services' in primary care: a retrospective observational study.Family medicine and community health · 2026Observational
- How Much Chronic Disease Out-of-Pocket Expenditure Runs Through Pain? A Prospective Counterfactual Decomposition of Five-Year Korean Panel Data.Medicina (Kaunas, Lithuania) · 2026Article
- Translating genomic data into healthcare practice with the Singapore National Precision Medicine program.Nature genetics · 2026Review
- Association Between Healthy Lifestyle Habits and Intrinsic Capacity Among Community-Dwelling Older Adults in Singapore.Nutrients · 2026Article
- Nurses as guardians of time: the hidden clinical value of continuous care in geriatrics.Frontiers in public health · 2026Review
- Rebalancing health investment across the life course: a high-value age segments framework for aging societies.Frontiers in public health · 2026Article
- Profiles of disability among youths in Singapore and their link to psychological distress and health care utilization.Frontiers in psychiatry · 2026Article
- Evaluating Value Beyond Efficacy: A Meta-Analytic Assessment of Inclisiran's Cost-Effectiveness in Cardiovascular Prevention.Healthcare (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Singapore's rapidly aging population and increasing healthcare demands highlight the need for projections to inform policy planning. Here we adapted a previously published dynamic Markov microsimulation model, the Future Elderly Model, to estimate disease trajectories and healthcare expenditure among adults aged 51 years and older in Singapore. The model simulated four long-term lifestyle interventions aligned with the Healthier SG program from 2020 to 2050. Our projections indicate an increasing prevalence of chronic conditions, comorbidities, obesity and disabilities, with ethnic differences. The projected lifetime healthcare expenditure is the highest among Indians (US $93,900; 95% credible interval (CI), US $68,900-119,000), followed by the Chinese (US $75,700; 95% CI, US $57,600-93,800) and Malays (US $70,000; 95% CI, US $52,000-88,000). Despite having a higher chronic disease burden, Malays are expected to incur lower lifetime expenditure due to their shorter life expectancy. Implementing all 4 interventions could save US $505 million (95% CI, US $462-547 million) in healthcare use by 2050. Sustained lifestyle interventions may moderate the increase in future burdens. Policy strategies should prioritize preventive care tailored to the specific needs of diverse population subgroups.
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