ArticleNature cell biology2025
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells.
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Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12citing papers in PubMed, 1 pooled it
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomics and metabolites in cancer diagnosis and treatment.Molecular biomedicine · 2025Pooled it
- Mechanisms of Hematopoietic Stem Cell Aging and Emerging Rejuvenation Strategies.Stem cell reviews and reports · 2026Review
- Hematopoietic stem cell aging: a review of transcriptional and multi-omics insights and potential paths for AI integration.Experimental & molecular medicine · 2026Review
- Immunometabolic Modulation of the Bone Marrow Niche by Bioactive Materials to Rescue Impaired Fracture Healing.Stem cell reviews and reports · 2026Review
- Metabolic profiling and perturbations of human CD34+ hematopoietic stem and progenitor cells to regulate HSPC function.Blood advances · 2026Article
- YY1 in hematopoietic stem cells: epigenetic regulation, chromatin architecture, and aging.Current opinion in hematology · 2026Review
- Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome.Nature cell biology · 2026Article
- ATP2B1 expression identifies human hematopoietic stem cells with superior repopulation and self-renewal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hematopoietic Aging and Leukemia: Mechanistic and Therapeutic Insights.International journal of molecular sciences · 2026Review
- Metabolic and epigenetic interplay in HSPC specification: A balance between extrinsic and intrinsic cues.iScience · 2026Review
- Intrinsic and niche-dependent metabolic regulation of haematopoietic stem cells and implications for leukaemogenesis.Nature cell biology · 2026Review
- Single-cell Raman profiling of B cell differentiation and leukemic transformation with transcriptome inference.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
38 authors.
Maria-Eleni Lalioti *Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Mari Carmen Romero-Mulero *Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0002-6705-7613
Noémie KarabaczMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Julian MessMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Helen DemollinMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Jasmin RettkowskiMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0009-0006-1504-0816
Konrad SchuldesMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Michael MittererMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Carolin WadleMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Khalid ShoumariyehDepartment of Medicine I - Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Mirijam EggMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Carlos Alfonso-GonzalezMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Karin JäckleinMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Katharina SchönbergerMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Nikolaos KarantzelisDepartment of Medicine I - Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Gregor ReisigDepartment of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Philipp AktoriesUniversity of Freiburg, Faculty of Biology, Freiburg, Germany.
Isabella M MayerLaboratory of Stem Cell Biology and Ageing, Department of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland.ORCID http://orcid.org/0000-0002-9164-9547
Ioanna TsoukalaGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Alexander SchäfferGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Irene Tirado-GonzalezGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Aurélien DugourdFaculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0714-028X
Lukas M BraunDepartment of Medicine I - Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-0770-4994
Beatriz Silva-RegoMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Michael-Jason JonesMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Katrin KierdorfCentre for Integrative Biological Signalling Studies, Freiburg, Germany.ORCID http://orcid.org/0000-0002-9272-4780
Julio Saez-RodriguezFaculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8552-8976
Kilian ReisingDepartment of Orthopedic Surgery and Traumatology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Sebastian Gottfried WalterDepartment of Orthopedics, Traumatology and Reconstructive Surgery, University Hospital Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-6203-8616
Hind MedyoufGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Valérie HilgersMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0002-4551-0931
Gabriel GhiaurDivision of Hematological Malignancies, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Hospital, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3955-7944
Robert ZeiserDepartment of Medicine I - Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-6565-3393
Darja KarpovaInstitute for Transfusion Medicine and Immunohematology, Goethe University Hospital Medical School, German Red Cross Blood Donor Service, Frankfurt am Main, Germany.
Simon RendersDepartment of Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Sascha GraviusDepartment of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Joerg BuescherMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. buescher@ie-freiburg.mpg.de.ORCID http://orcid.org/0000-0002-6547-0076
Nina Cabezas-WallscheidMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. nina.cabezas@hest.ethz.ch.ORCID http://orcid.org/0000-0003-0870-0530
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic cues are crucial for regulating haematopoietic stem and progenitor cells (HSPCs). However, the metabolic profile of human HSPCs remains poorly understood due to the limited number of cells and the scarcity of bone marrow samples. Here we present the integrated metabolome, lipidome and transcriptome of human adult HSPCs (lineage
Indexed as
AgingBone Marrow CellsCell DifferentiationCellular SenescenceHematopoietic Stem CellsLeukemia, Myeloid, AcuteMetabolomeAdultCells, CulturedCholineHumansLipid MetabolismLipidomicsMetabolomicsTranscriptomeCholine
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