ArticleNature genetics2025
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.
Abstract read
In one paragraph
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Germline homologous recombination deficiency influences TP53-mutant clonal hematopoiesis fitness during platinum and PARP inhibitor treatment.Nature genetics · 2026Article
- Predictive modeling of clonal hematopoiesis across diverse cohorts.Blood advances · 2026Article
- Preemptive hematopoietic stem cell transplantation inHaematologica · 2026Article
- The Evolution of Polyclonal Competition in Aging Hematopoiesis.Cancer discovery · 2026Article
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- Diagnosis and management of neutropenia in adults: Expert guidance.British journal of haematology · 2026Review
- Patterns and drivers of 43,617 mosaic chromosomal alterations in blood.Nature genetics · 2026Article
- Loss of chromosome Y in hematopoietic cells: mechanisms and implications for human disease.MedScience · 2026Review
- Immunological consequences of chemotherapy: implications for cancer immunotherapy.Journal for immunotherapy of cancer · 2026Review
- Inherited DNA repair variants are associated with clonal hematopoiesis and cardiovascular risk in men with metastatic prostate cancer.Haematologica · 2026Article
- Clonal hematopoiesis and its progression to myeloid neoplasms: insights into risk, biology, and therapeutic strategies.Haematologica · 2026Review
- Clinical relevance of mosaic variants detected by exome sequencing.The Journal of allergy and clinical immunology · 2026Article
- CHIP ahoy: charting a decade of discovery in clonal hematopoiesis.Haematologica · 2026Review
- Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities.Journal of periodontology · 2026Review
- Frequent and clinically relevant germline DNA repair gene variants in young and familial myeloproliferative neoplasms.Blood cancer journal · 2026Article
- GATES: A Lightweight Tool Automating Pathogenic Variant Discovery From Raw Whole-Exome Sequencing Data.Cancer informatics · 2026Article
- Demystifying the diagnosis and management of ICUS, CHIP, and CCUS.Hematology. American Society of Hematology. Education Program · 2025Review
- Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations.Human genomics · 2025Article
- Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood.medRxiv : the preprint server for health sciences · 2025Article
- Closing the loop: Teaching single-cell foundation models to learn from perturbations.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors.
Jie LiuCancer Biology Graduate Program, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6365-1888
Duc TranDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-2918-8601
Liying XueProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Brian J WileyDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Caitlyn VlasschaertDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Caroline J WatsonEarly Cancer Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8351-268X
Hamish A J MacGregorEarly Cancer Institute, University of Cambridge, Cambridge, UK.
Xiaoyu ZongDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Irenaeus C C ChanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Indraniel DasDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Md Mesbah UddinProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1846-0411
Abhishek NiroulaProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5904-0635
Gabriel GriffinProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4042-6757
Benjamin L EbertProgram in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0197-5451
Taralynn MackDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1043-2950
Yash PershadDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-2282-1403
Brian SharberDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0009-0005-9598-8211
Michael BergerMemorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3882-5000
Ahmet ZehirMemorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-5406-4104
Ryan PtashkinMemorial Sloan-Kettering Cancer Center, New York, NY, USA.
Ross L LevineMemorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7884-1905
Elli PapaemmanuilMemorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1709-8983
Vijai JosephMemorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7933-151X
Teng GaoMemorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0196-689X
Yelena KemelMemorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5042-5651
Diana MandelkerMemorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4154-0567
Konrad H StopsackDepartment of Epidemiologic Methods and Etiologic Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS and Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany.ORCID http://orcid.org/0000-0002-0722-1311
Paul D P PharoahDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8494-732X
Semanti MukherjeeMemorial Sloan-Kettering Cancer Center, New York, NY, USA.
Li DingDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-1517-2975
Yin CaoDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-9835-7662
Matthew J WalterDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-7753-1091
Jamie R BlundellEarly Cancer Institute, University of Cambridge, Cambridge, UK.
Nilanjan ChatterjeeDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9060-008X
Kenneth OffitMemorial Sloan-Kettering Cancer Center, New York, NY, USA.
Lucy A GodleyDivision of Hematology/Oncology, Department of Medicine, and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1914-9158
Daniel C Link *Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-3170-7581
Zsofia K Stadler *Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6985-2864
Alexander G Bick *Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Pradeep Natarajan *Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kelly L Bolton *Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. bolton@wustl.edu.ORCID http://orcid.org/0000-0001-6584-3357
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MTargeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI Daniel C Link · 2013 to 2026
$31.6MClonal Hematopoiesis Aging Resiliency MechanismsR01AG088657 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Alexander Bick, Siddhartha Jaiswal · 2024 to 2026
$6.6MClonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9MEstablishing the dynamics of lymphoid clonal hematopoiesis and its aging-related disease consequencesR01AG083736 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul L. Auer, Alexander Bick · 2023 to 2026
$2.8MIntegrated omics analysis of clonal hematopoiesis and cardiovascular disease risk in TOPMedR01HL168894 · NHLBI · EMORY UNIVERSITY · PI Karen Conneely, Pradeep Natarajan · 2023 to 2026
$2.6MTargeting Clonal Hematopoiesis of Indeterminate Potential Using Human GeneticsDP5OD029586 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BICK, ALEXANDER · 2020 to 2024
$2.3MNCI NIH HHS P30 CA008748NCI NIH HHS P50 CA171963NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL168894NIA NIH HHS R01 AG083736NIA NIH HHS R01 AG088657NIH HHS DP5 OD029586
Abstract
With age, clonal expansions occur pervasively across normal tissues yet only in rare instances lead to cancer, despite being driven by well-established cancer drivers. Characterization of the factors that influence clonal progression is needed to inform interventional approaches. Germline genetic variation influences cancer risk and shapes tumor mutational profile, but its influence on the mutational landscape of normal tissues is not well known. Here we studied the impact of germline genetic variation on clonal hematopoiesis (CH) in 731,835 individuals. We identified 22 new CH-predisposition genes, most of which predispose to CH driven by specific mutational events. CH-predisposition genes contribute to unique somatic landscapes, reflecting the influence of germline genetic backdrop on gene-specific CH fitness. Correspondingly, somatic-germline interactions influence the risk of CH progression to hematologic malignancies. These results demonstrate that germline genetic variation influences somatic evolution in the blood, findings that likely extend to other tissues.
Indexed as
Clonal HematopoiesisGenetic VariationGerm-Line MutationHematologic NeoplasmsNeoplasmsDisease ProgressionFemaleGenetic Predisposition to DiseaseHumansMale
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.