Evidence map›Paper›PMID 40664755›Full record

ArticleScientific reports2025

Serum untargeted metabolomics alterations in systemic lupus erythematosus patients with elevated serum ferritin.

Na Li, Rui Chai, Xue Xu, Qian Xu, Jun Liang, Dandan Wang, Huayong Zhang, Xuebing Feng, Linyu Geng, Lingyun Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Na Li *Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Rui Chai *Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Xue XuDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Qian XuDivision of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Jun LiangDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Dandan WangDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Huayong ZhangDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Xuebing FengDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Linyu GengDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. genglinyu1987@163.com.
Lingyun SunDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. lingyunsun2012@163.com.

Funding

funding for Clinical Trials from the Affiliated Drum Tower Hospital, Medical School of Nanjing University 2021-LCYJ-PY-16Nanjing Medical Science and Technique Development Foundation JQX20004National Key Research and Development Program of China 2020YFA0710800the Key Program of National Natural Science Foundation of China 82330055
6 · The paper itself

Abstract

This study investigated the alterations in serum metabolic profile in systemic lupus erythematosus (SLE) patients with increased levels of serum ferritin. 52 SLE patients were divided into two groups based on their ferritin levels. The metabolomic profile was identified using non-targeted metabolomics technology (UHPLC-MS/MS), and analyzed by Principal Component Analysis (PCA), Orthogonal Partial Least Squares Discrimination Analysis (OPLS-DA), ROC analysis, and pathway analysis. Results showed that SLE patients with high ferritin levels had increased hematologic involvement and elevated levels of inflammatory markers, including procalcitonin (PCT), alanine transaminase (ALT), and aspartate transaminase (AST). Additionally, there was decreased levels of albumin and CD4

Indexed as

FerritinsLupus Erythematosus, SystemicMetabolomeMetabolomicsAdultAlanine TransaminaseAspartate AminotransferasesBiomarkersFemaleHumansMaleMiddle AgedPrincipal Component AnalysisAlanine TransaminaseAspartate AminotransferasesBiomarkersFerritinsMetabolomicsSerum ferritinSystemic lupus erythematosus

Identifiers

PMID40664755
PMCPMC12264283

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.