ArticleScientific reports2025
COVID-19 susceptibility, severity, and vaccine effectiveness in patients with psoriasis: a nationwide cohort study in South Korea.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Skin as a Potential Entry Point for SARS-CoV-2 Virus.International journal of molecular sciences · 2026Article
- SKIN AS A POTENTIAL ENTRY POINT FOR SARS-COV-2.bioRxiv : the preprint server for biology · 2026Article
- Dietary patterns and psoriasis severity in Thai patients: a machine learning approach for small sample data.Scientific reports · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with psoriasis are vulnerable to infections due to dysregulated immunity, use of immunosuppressive drugs, and comorbid conditions. Despite ongoing concerns regarding coronavirus disease 2019 (COVID-19) vulnerability in patients with psoriasis, evidence remains limited. This nationwide, population-based, retrospective cohort study aimed to assess the risk and severity of COVID-19 and vaccine effectiveness in patients with psoriasis, including those receiving immunomodulatory therapy, using Korean National Health Insurance Service claims data from 2018 to 2021. The primary analysis included 167,746 patients with psoriasis and 866,582 controls, revealing no significant associations between psoriasis and COVID-19 (adjusted hazard ratio [aHR]: 0.99, 95% confidence interval [CI]: 0.95-1.04). Conversely, the secondary analysis of 3,131 patients with psoriasis and 265,475 controls revealed significantly higher rates of severe COVID-19 in patients with psoriasis (aHR: 1.33, 95% CI: 1.08-1.64). While some treatment subgroups - such as the cyclosporine and methotrexate subgroups - demonstrated higher incidences of COVID-19 than the reference (nonsystemic) subgroup, these differences were not statistically significant. Furthermore, vaccine interaction effects between the duration of immunity and psoriasis or each treatment were insignificant (all P > 0.05). Patients with psoriasis exhibited a higher risk of severe COVID-19; however, their COVID-19 susceptibility and vaccine effectiveness resembled those of the control group. Additionally, the use of immunomodulatory agents did not impact COVID-19 risk or vaccine effectiveness. These findings highlight the need for dermatologists to implement pre- and postinfection strategies tailored for patients with psoriasis.
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