Evidence map›Paper›PMID 40664725›Full record

ArticleScientific reports2025

Counteracting methicillin resistant Staphylococcus aureus through novel Citral-Azithromycin combination.

Hitesh K Sharma, Ibha Singh, Amarnath Karna, Puneet Gupta, Taru Singh, Anoop Kumar, Deepti Pandita, Monalisa Mukherjee, Virinder S Parmar, Pallavi Agarwal and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hitesh K SharmaAmity Institute of Pharmacy, Amity University Uttar Pradesh, Sector 125, Noida, 201313, India.
Ibha SinghAmity Institute of Molecular Medicine and Stem Cell Research, Amity University, Uttar Pradesh, Sector 125, Noida, 201313, India.
Amarnath KarnaAmity Institute of Molecular Medicine and Stem Cell Research, Amity University, Uttar Pradesh, Sector 125, Noida, 201313, India.
Puneet GuptaAmity Institute of Pharmacy, Amity University Uttar Pradesh, Sector 125, Noida, 201313, India.
Taru SinghAmity Institute of Biotechnology, Amity University, Sector 125, Noida, 201313, India.
Anoop KumarDepartment of Pharmacology, Delhi Pharmacological Sciences and Research University (DPSRU), New Delhi, 110017, India.
Deepti PanditaDepartment of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences & Research (DIPSAR) Delhi Pharmaceutical Sciences and Research University, New Delhi, India.
Monalisa MukherjeeAmity Institute of Click Chemistry and Research Studies, Amity University Uttar Pradesh, Sector 125, Noida, 201313, India.
Virinder S ParmarAmity Institute of Click Chemistry and Research Studies, Amity University Uttar Pradesh, Sector 125, Noida, 201313, India.
Pallavi AgarwalAmity Institute of Molecular Medicine and Stem Cell Research, Amity University, Uttar Pradesh, Sector 125, Noida, 201313, India.
Viney LatherAmity Institute of Pharmacy, Amity University Uttar Pradesh, Sector 125, Noida, 201313, India. vlather@amity.edu.

Funding

Indian Council of Medical Research ICMR File No. (No. AMR/Fellowship/7/2020-ECD-II)
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant challenge, necessitating novel therapeutic strategies. This study demonstrates the synergistic bactericidal activity of citral, a phytochemical, and azithromycin against clinical MRSA isolates. Checkerboard assays confirmed synergy with a fractional inhibitory concentration index (FICI) of 0.093, while time-kill kinetics showed a reduction in bacterial viability from 5.39 to 2.94 log

Indexed as

Acyclic MonoterpenesAnti-Bacterial AgentsAzithromycinMethicillin-Resistant Staphylococcus aureusCell SurvivalDrug SynergismFibroblastsHumansMicrobial Sensitivity TestsMicrobial ViabilityStaphylococcal InfectionsAcyclic MonoterpenesAnti-Bacterial AgentsAzithromycincitral

Identifiers

PMID40664725
PMCPMC12263860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.