Evidence map›Paper›PMID 40664695›Full record

ArticleScientific reports2025

Potential utility of salivary gland amyloid uptake as a surrogate marker for adipose tissue and amyloid-beta dynamics based on its association with BMI and cerebral amyloid burden.

Kyu Ri Kim, Kyungmin Kim, Ji-Young Kim, Hai-Jeon Yoon

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. JACC. Advances · 2026
    Article
  2. Salivary Gland Uptake onBrain and behavior · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kyu Ri Kim *Ewha Womans University College of Medicine, 25, Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07804, Republic of Korea.
Kyungmin Kim *Ewha Womans University College of Medicine, 25, Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07804, Republic of Korea.
Ji-Young KimDepartment of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, 07804, Republic of Korea.
Hai-Jeon YoonDepartment of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, 07804, Republic of Korea. haijeon.yoon@gmail.com.

Funding

National Research Foundation of Korea RS-2024-00453521, NRF-2020R1A5A2019210
6 · The paper itself

Abstract

Recent studies have noted an unexpected inverse correlation between body mass index (BMI) and cerebral amyloid-beta (Aβ) deposition, suggesting a potential involvement of adipose tissue in AD pathology. Given the adipose-rich nature of salivary glands, we investigated whether Aβ uptake in the salivary glands is associated with the link between BMI and cerebral Aβ deposition using

Indexed as

Adipose TissueAlzheimer DiseaseAmyloidAmyloid beta-PeptidesBody Mass IndexBrainSalivary GlandsAgedAged, 80 and overBiomarkersCognitive DysfunctionFemaleHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyAmyloidAmyloid beta-PeptidesBiomarkersAdipose tissueAlzheimer’s diseaseAmyloid PETBody mass indexStandardized uptake value ratio of salivary glands (SUVRSG)

Identifiers

PMID40664695
PMCPMC12263871

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.