Evidence map›Paper›PMID 40664681›Full record

ArticleNPJ Parkinson's disease2025

Classification of Parkinson's disease and isolated REM sleep behaviour disorder: delineating progression markers from the sebum volatilome.

Caitlin Walton-Doyle, Beatrice Heim, Eleanor Sinclair, Sze Hway Lim, Katherine A Hollywood, Joy Milne, Evi Holzknecht, Ambra Stefani, Birgit Högl, Klaus Seppi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Trained dogs can detect the odor of Parkinson's disease.Journal of Parkinson's disease · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Caitlin Walton-DoyleMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Manchester, M1 7DN, UK.
Beatrice HeimDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Eleanor SinclairMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Manchester, M1 7DN, UK.
Sze Hway LimDepartment of Neurology, Salford Royal Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, M6 8HD, Manchester, UK.
Katherine A HollywoodMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Manchester, M1 7DN, UK.
Joy MilneMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Manchester, M1 7DN, UK.
Evi HolzknechtDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Ambra StefaniDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-4259-8824
Birgit HöglDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Klaus SeppiDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Monty SilverdaleDepartment of Neurology, Salford Royal Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, M6 8HD, Manchester, UK.ORCID http://orcid.org/0000-0002-3295-6897
Werner PoeweDepartment of Neurology, Innsbruck Medical University, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-4367-0971
Perdita BarranMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Manchester, M1 7DN, UK. perdita.barran@manchester.ac.uk.ORCID http://orcid.org/0000-0002-7720-586X
Drupad K TrivediMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Manchester, M1 7DN, UK. drupad.trivedi@manchester.ac.uk.ORCID http://orcid.org/0000-0001-7969-0195

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) 2113640RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/L015048/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X019950/1
6 · The paper itself

Abstract

Parkinson's Disease (PD) has been associated with a distinct odour, emanating from the skin and strongest in sebum-rich areas. Here, volatile components from sebum were analysed directly with Thermal Desorption Gas Chromatography - Mass Spectrometry. We analysed samples from subjects with clinically established PD (n = 46), controls (n = 28) and participants with isolated REM sleep behaviour disorder (iRBD, n = 9) to investigate metabolite changes in probable prodromal PD. We found 55 significant features where abundance from individuals with iRBD was intermediate between PD and control and assigned putative identifications. Olfactory analysis of the iRBD samples showed three classified as PD, of which two displayed PD symptoms on clinical follow-up. Further, we analysed PD participants sampled at yearly intervals and investigated features displaying regulation over the visits. Our findings support the use of sebum as an accessible biofluid, rich with measurable volatile compounds that alter in abundance in individuals with PD and iRBD.

Identifiers

PMID40664681
PMCPMC12264129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.