Evidence map›Paper›PMID 40664664›Full record

ArticleScientific data2025

24-hour simultaneous mPFC's miniature 2-photon imaging, EEG-EMG, and video recording during natural behaviors.

Jiaying Han, Fangxu Zhou, Zhong Zhao, Dong Zhang, Xueli Chen, Li Wang, Ting Zhao, Wei Ye, Xiaochun Gu, Huaqiang Fang and 3 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiaying Han *Academy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.ORCID 0000-0001-6602-0707
Fangxu Zhou *College of Future Technology, Peking University, 100871, Beijing, China. zhoufangxu@pku.edu.cn.ORCID 0009-0009-6637-2783
Zhong ZhaoPKU-Nanjing Institute of Translational Medicine, Nanjing Raygen Health, 211899, Nanjing, China.
Dong ZhangAcademy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.
Xueli ChenPKU-Nanjing Institute of Translational Medicine, Nanjing Raygen Health, 211899, Nanjing, China.
Li WangPKU-Nanjing Institute of Translational Medicine, Nanjing Raygen Health, 211899, Nanjing, China.
Ting ZhaoPKU-Nanjing Institute of Translational Medicine, Nanjing Raygen Health, 211899, Nanjing, China.
Wei YePKU-Nanjing Institute of Translational Medicine, Nanjing Raygen Health, 211899, Nanjing, China.
Xiaochun GuPKU-Nanjing Institute of Translational Medicine, Nanjing Raygen Health, 211899, Nanjing, China.
Huaqiang FangPKU-Nanjing Institute of Translational Medicine, Nanjing Raygen Health, 211899, Nanjing, China.
Jue ZhangAcademy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.
Lifeng ZhangPKU-Nanjing Institute of Translational Medicine, Nanjing Raygen Health, 211899, Nanjing, China. lfzhang916@hotmail.com.
Heping ChengAcademy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.ORCID 0000-0002-9604-6702

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD0202205Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD0204000Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022ZD0211903
6 · The paper itself

Abstract

The medial prefrontal cortex (mPFC) coordinates cognitive processes across multiple timescales, yet its role in multiple natural behaviors remain unclear. Existing neural recording methods are limited by short observation windows and artificial task constraints, preventing insights into extended, naturally relevant dynamics. Here, we present multimodal datasets integrating two-photon calcium imaging via miniature microscope, simultaneous behavior video recording, and continuous EEG-EMG recordings in freely moving mice for over 24 hours. These datasets capture uninterrupted neural activity (unconstrained calcium imaging), physiological rhythms, and naturalistic behaviors (12 classified states) across full circadian cycles. By bridging three critical gaps: long-term continuity (over 24 hours of recording), multiple spontaneous behavior (unrestrained freely moving mice), and multimodal integration (neural activity, brain states, and behavior), our work establishes an open-access benchmark for naturalistic neuroscience. These data enable investigations into how mPFC ensembles dynamically reconfigure across timescales, advancing computational models of cortical dynamics and offering new insights into experience-dependent plasticity and cross-modal interactions in real-world contexts.

Indexed as

Behavior, AnimalPrefrontal CortexAnimalsElectroencephalographyMiceVideo Recording

Identifiers

PMID40664664
PMCPMC12264145

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.