Evidence map›Paper›PMID 40664660›Full record

ArticleScientific data2025

Integrated genomic analysis of NF1-associated peripheral nerve sheath tumors: an updated biorepository dataset.

Jineta Banerjee, Yang Lyu, Stavriani C Makri, Alexandra J Scott, Lindy Zhang, Ana Calizo, Kai Pollard, Kuangying Yang, John M Gross, Calixto-Hope G Lucas and 8 more

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jineta Banerjee *Sage Bionetworks, Seattle, WA, USA.
Yang Lyu *Division of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University St. Louis (WUSTL), Saint Louis, MO, USA.
Stavriani C Makri *Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0008-6940-9468
Alexandra J ScottSage Bionetworks, Seattle, WA, USA.
Lindy ZhangDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ana CalizoCellular and Molecular Medicine Program, Johns Hopkins University, Baltimore, MD, USA.
Kai PollardPersonal Genome Diagnostics, Baltimore, MD, USA.
Kuangying YangDivision of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University St. Louis (WUSTL), Saint Louis, MO, USA.ORCID 0000-0002-6992-9585
John M GrossDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Calixto-Hope G LucasDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8347-9592
Jiawan WangDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2137-1826
Adam S LevinDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Allan J BelzbergDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Carlos G RomoDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Robert J AllawaySage Bionetworks, Seattle, WA, USA.ORCID 0000-0003-3573-3565
Jaishri O BlakeleyDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Angela C HirbeDivision of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University St. Louis (WUSTL), Saint Louis, MO, USA.
Christine A PratilasDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. cpratil1@jhmi.edu.ORCID 0000-0002-7116-0605

Funding

LAB RESEARCH TRAINING IN PEDIATRIC ONCOLOGY-HEMATOLOGYT32CA060441 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN D FRIEDMAN · 1993 to 2026
$14.9M
NCI NIH HHS T32 CA060441
6 · The paper itself

Abstract

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous condition that predisposes to the development of peripheral nerve sheath tumors (PNST) including cutaneous neurofibromas (CNF), plexiform neurofibromas (PNF), atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP), and malignant peripheral nerve sheath tumors (MPNST). The Johns Hopkins NF1 biospecimen repository promotes the successful advancement of therapeutic developments for NF1-associated PNST through acquisition and genomic analysis of human tumor specimens. RNA sequencing (RNAseq) and whole exome sequencing (WES) data were generated from 73 and 114 primary human tumor samples, respectively. These pre-processed data, standardized for immediate computational analysis, are accessible through the NF Data Portal, allowing immediate interrogation. This dataset combines new and previously released samples, offering a comprehensive view of the entire cohort sequenced. As a dedicated effort to systematically bank tumor samples from people with NF1, in collaboration with molecular geneticists and computational biologists, the Johns Hopkins NF1 biospecimen repository offers access to tissue samples and genomic data to promote the advancement of NF1-related tumor biologic insights and therapies.

Indexed as

Nerve Sheath NeoplasmsNeurofibromatosis 1Exome SequencingGenomicsHumans

Identifiers

PMID40664660
PMCPMC12263889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.