ArticleNature communications2025
The impact of highly pathogenic avian influenza H5N1 virus infection on dairy cows.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Evolving dynamics of H5Nx avian influenza in China revealed by long-term wild bird surveillance.Nature communications · 2026Article
- Characterization of bovine-derived H5N1 viruses expressing fluorescent and luminescent reporter proteins.The Journal of general virology · 2026Article
- Empowering One Health with metagenomics.One health outlook · 2026Review
- Innate Pathway Selection Modulates Antibody and T-Cell Responses to Mosaic Influenza Nucleoprotein in Cattle.Viruses · 2026Article
- Migratory Bird and Marine Mammal Surveillance Fails to Find Evidence for an HPAI H5N1 2.3.4.4b Incursion Into Australia in 2025.Influenza and other respiratory viruses · 2026Article
- Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriers.Nature communications · 2026Article
- Mammary and respiratory infection of sheep with H5Nx clade 2.3.4.4b viruses with milk-mediated transmission to lambs.Science advances · 2026Article
- Dual-route H5N1 vaccination induces systemic and mucosal immunity in murine and bovine models.NPJ vaccines · 2026Article
- Inactivation of Avian Influenza Virus in Raw Milk Kefir.Food and environmental virology · 2026Article
- Evaluation of an H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccine in lactating dairy cows.bioRxiv : the preprint server for biology · 2026Article
- Novel recombinant H5-based vaccine provides effective protection against H5N1 influenza virus in cats.NPJ vaccines · 2026Article
- Avian Influenza Viruses: Global Panzootic, Host Range Expansion and Emerging One-Health Threats.Veterinary sciences · 2026Review
- Manure management during African swine fever outbreak: identifying gaps through a narrative review.Frontiers in veterinary science · 2026Review
- Modeling of H5N1 influenza virus kinetics during dairy cattle infection suggests the timing of infectiousness.PLoS biology · 2026Article
- High immune responder cows have lower treatment risk and reduced milk loss during highly pathogenic avian influenza H5N1 outbreaks.JDS communications · 2026Article
- Insights into cow-level risk factors for highly pathogenic avian influenza H5N1 clinical disease in lactating Holsteins from a single outbreak in Colorado: An observational study.JDS communications · 2026Article
- Distinct influenza interfaces in cattle: repeated spillovers of highly pathogenic avian influenza A(H5N1) from wild birds and enzootic circulation of influenza D virus.Frontiers in cellular and infection microbiology · 2026Review
- Article
- Influenza A Virus H5N1 Subtype: Resurgent Interspecies and Intercontinental Transmission, and a New Host.Pathogens (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly pathogenic avian influenza (HPAI) H5N1 virus has been associated with severe mastitis in dairy cows, leading to decreased milk production. Here we investigated the impact of H5N1 virus infection in health and production parameters in an affected dairy herd in Ohio. Clinical disease, which lasted for about three weeks, was recorded in 20.0% (777/3876) of the adult cows. Milk losses of ~900 kg per cow were recorded in affected cows during a 60 day-post-outbreak period. Seroprevalence was 89.4% (570/637) in the herd, with 76.1% (485/637) of seropositive animals being subclinically infected. Clinically affected cows presented an increased risk of death (6 times) and of premature herd removal (3.6 times) when compared to non-clinical cows. Economic losses due to decreased milk production, mortality, and early herd removal were estimated at $950 per clinically affected cow for a total cost of ~$737,500 for the herd during the observation period. Our results demonstrate a production impact lasting at least 60 days post-clinical diagnosis and major financial consequences of HPAI H5N1 virus infection to dairy farms.
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