ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Functional Alterations in Parvalbumin-Positive Interneurons after Traumatic Brain Injury in Somatosensory Cortex of Mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Traumatic brain injury (TBI) can lead to long-lasting cognitive deficits in the human brain, with a considerable contribution of secondary morphological and functional sequela in cortical regions distant to the lesion site. In order to uncover the role of early functional alterations in parvalbumin-positive basket cells (PV-BCs), an interneuron population required to maintain inhibition of neocortical circuits, to this dysfunctional plasticity, we investigated anatomical and electrophysiological properties of PV-BCs in PV-IRES-Cre-tdTomato mice of both sexes 24 h after a cortical impact. These experiments revealed that the number of PV-BCs was moderately decreased around the cortical impact site, while their morphology was unaffected. Patch-clamp experiments demonstrated that TBI increased the input resistance of PV-BCs and the amplitude of hyperpolarization-activated inward currents (
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