Evidence map›Paper›PMID 40664466›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie

Association between preoperative proton pump inhibitor use and postoperative infectious and renal complications following major elective surgery.

Luc Dubois, J Andrew McClure, Philip M Jones, Marko Mrkobrada, Suzanne Flier, Blayne Welk, Kelly Vogt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luc DuboisFrom the Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Mrkobrada, Welk, Vogt); London Health Sciences Centre, London, Ont. (Dubois, McClure, Jones, Mrkobrada, Flier, Welk, Vogt); ICES Western, London, Ont. (Dubois, Jones, Welk); the Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Jones, Welk); the Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Jones, Flier) luc.dubois@lhsc.on.ca.
J Andrew McClureFrom the Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Mrkobrada, Welk, Vogt); London Health Sciences Centre, London, Ont. (Dubois, McClure, Jones, Mrkobrada, Flier, Welk, Vogt); ICES Western, London, Ont. (Dubois, Jones, Welk); the Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Jones, Welk); the Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Jones, Flier).
Philip M JonesFrom the Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Mrkobrada, Welk, Vogt); London Health Sciences Centre, London, Ont. (Dubois, McClure, Jones, Mrkobrada, Flier, Welk, Vogt); ICES Western, London, Ont. (Dubois, Jones, Welk); the Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Jones, Welk); the Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Jones, Flier).
Marko MrkobradaFrom the Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Mrkobrada, Welk, Vogt); London Health Sciences Centre, London, Ont. (Dubois, McClure, Jones, Mrkobrada, Flier, Welk, Vogt); ICES Western, London, Ont. (Dubois, Jones, Welk); the Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Jones, Welk); the Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Jones, Flier).
Suzanne FlierFrom the Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Mrkobrada, Welk, Vogt); London Health Sciences Centre, London, Ont. (Dubois, McClure, Jones, Mrkobrada, Flier, Welk, Vogt); ICES Western, London, Ont. (Dubois, Jones, Welk); the Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Jones, Welk); the Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Jones, Flier).
Blayne WelkFrom the Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Mrkobrada, Welk, Vogt); London Health Sciences Centre, London, Ont. (Dubois, McClure, Jones, Mrkobrada, Flier, Welk, Vogt); ICES Western, London, Ont. (Dubois, Jones, Welk); the Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Jones, Welk); the Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Jones, Flier).
Kelly VogtFrom the Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Mrkobrada, Welk, Vogt); London Health Sciences Centre, London, Ont. (Dubois, McClure, Jones, Mrkobrada, Flier, Welk, Vogt); ICES Western, London, Ont. (Dubois, Jones, Welk); the Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Dubois, Jones, Welk); the Department of Anesthesia & Perioperative Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont. (Jones, Flier).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUse of poton pump inhibitors (PPIs) is associated with increased risk of

methodsIn this population-based, matched cohort study, we identified patients who had filled a PPI prescription within 90 days before major elective surgery (2010-2019). Study outcomes included

resultsOf 313 163 patients, 89 047 (28.4%) used PPIs; of those, 79 681 were successfully matched to patients who did not use PPIs. The risk of the composite outcome (acute kidney injury, pneumonia,

conclusionWe found that preoperative PPI use was associated with higher rates of pneumonia, particularly among patients undergoing hip and knee replacement surgery, and lower rates of gastrointestinal bleeding. Patients taking a PPI before surgery should be targeted for therapies aimed at reducing pneumonia risk, such as aggressive chest physiotherapy, following their operation.

Indexed as

Acute Kidney InjuryClostridium InfectionsElective Surgical ProceduresPneumoniaPostoperative ComplicationsProton Pump InhibitorsAgedClostridioides difficileFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsProton Pump Inhibitors

Identifiers

PMID40664466
PMCPMC12279390

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.