ArticleJournal for immunotherapy of cancer2025
Engineered red blood cell extracellular vesicles for delivery of Dox and siIDO1 enhance targeted chemo-immunotherapy of acute myeloid leukemia.
Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Y-RBCEVs accelerate fracture repair through osteogenesis and VCAN-mediated CD44/PI3K/AKT-dependent macrophage polarization.Bioactive materials · 2027Article
- Engineered small extracellular vesicles in hematologic malignancies: mechanisms, therapeutic strategies, and translational challenges.Clinical and experimental medicine · 2026Review
- Application of dendritic cell extracellular vesicles as a valid nanoparticle platform for cancer therapies: a narrative review.Stem cell research & therapy · 2026Review
- Cell- and biological-based drug delivery vectors for cancer treatment.Frontiers in molecular biosciences · 2026Review
- Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility.Open medicine (Warsaw, Poland) · 2025Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a malignancy of hematopoietic origin, the standard-of-care cytoreductive chemotherapy can not provide satisfactory treatment effect for patients with acute myeloid leukemia (AML). Immunotherapy has received increasing attention in leukemia treatment. However, the immunosuppressive microenvironment and low cancer immunogenicity of AML blasts create major obstacles to effectively inducing immune responses.
methodsWe developed an extracellular vesicle-based dual-delivery biosystem, which enhanced anti-AML immune responses by activating the immunogenicity of leukemia cells and relieving immunosuppression in AML allografted mice. Red blood cell-derived extracellular vesicles (REVs) were selected as delivery carriers due to the excellent biocompatibility. REVs were ligated with leukemia-targeting peptide P9 and subsequently loaded with immunogenic cell death (ICD) inducer (Doxorubicin, Dox) and indoleamine 2,3-dioxygenase-1 siRNA (siIDO1) to construct a chemoimmunological cascade biosystem (REVs-Dox/siIDO1-P9).
resultsThe biosystem can specifically deliver the loaded Dox and siIDO1 into target leukemia cells and was validated capable of inducing efficient ICD. ICD-mediated release of damage-associated molecular patterns synergistically functions with siIDO1-mediated IDO1 silence to effectually recruit CD8
conclusionOur findings indicate that the extracellular vesicle-based chemoimmunological cascade biosystem provides a novel strategy for AML treatment.
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