Evidence map›Paper›PMID 40664398›Full record

ArticleInternational journal of epidemiology2025

Childhood cancer incidence around nuclear installations in Great Britain, 1995-2016.

Bethan Davies, Frédéric B Piel, Aina Roca-Barceló, Anna Freni Sterrantino, Hima Iyathooray Daby, Marta Blangiardo, Daniela Fecht, Frank de Vocht, Paul Elliott, Mireille B Toledano

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In one paragraph

Article in International journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bethan DaviesUK Small Area Health Statistics Unit (SAHSU), Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, White City Campus, London, United Kingdom.ORCID 0000-0002-6585-7641
Frédéric B PielUK Small Area Health Statistics Unit (SAHSU), Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, White City Campus, London, United Kingdom.ORCID 0000-0001-8131-7728
Aina Roca-BarcelóNIHR Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Imperial College London, White City Campus, London, United Kingdom.
Anna Freni SterrantinoMRC Centre for Environment and Health, School of Public Health, Imperial College London, White City Campus, London, United Kingdom.
Hima Iyathooray DabyUK Small Area Health Statistics Unit (SAHSU), Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, White City Campus, London, United Kingdom.
Marta BlangiardoNIHR Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Imperial College London, White City Campus, London, United Kingdom.
Daniela FechtUK Small Area Health Statistics Unit (SAHSU), Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, White City Campus, London, United Kingdom.ORCID 0000-0002-0738-0013
Frank de VochtPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Paul ElliottUK Small Area Health Statistics Unit (SAHSU), Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, White City Campus, London, United Kingdom.
Mireille B ToledanoNIHR Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Imperial College London, White City Campus, London, United Kingdom.ORCID 0000-0001-5695-6210

Funding

Health Protection Research Unit in Chemical and Radiation Threats and Hazards NIHR-200922National Institute for Health and Care Research
6 · The paper itself

Abstract

backgroundConcerns remain about the potential harmful health impact of nuclear installations. Historical clusters of leukaemia and non-Hodgkin's lymphoma (LNHL) in children living near Sellafield and Dounreay installations in Great Britain remain aetiologically unexplained, and the sites remain under surveillance. We assess the risk of LNHL, central nervous system (CNS) and all solid tumours in children aged 0-14 years living within 25 km of nuclear installations in Great Britain, between 1995 and 2016.

methodsWe used a Poisson regression model to estimate the expected number of cases of each cancer type at the community-level in the study population, we present standardized incidence ratios compared to the national population. We used a hierarchical Poisson regression model to estimate the adjusted incidence rate ratios for each cancer type by distance between the community of residence and nearest nuclear installation.

resultsWe found no evidence of elevated incidence of LNHL, CNS, or all solid tumours in children resident in communities in proximity to nuclear sites. Within the 25-km zone, there was no evidence of an increased risk of childhood cancer in communities closer to installations.

conclusionIn post-1994 data, there was no evidence of an increased risk of childhood cancers in communities within 25 km of nuclear installations in Great Britain. Previously raised risks are no longer evident.

Indexed as

Environmental ExposureLymphoma, Non-HodgkinNeoplasmsNeoplasms, Radiation-InducedNuclear Power PlantsAdolescentCentral Nervous System NeoplasmsChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMalePoisson Distributionepidemiologynuclear installationspaediatric cancer

Identifiers

PMID40664398
PMCPMC12263190

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.