ArticleGait & posture2025
Peak, cumulative and rate of medial and lateral compartment joint loading during gait following total knee arthroplasty.
Article in Gait & posture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundMany adults undergo a contralateral total knee arthroplasty (TKA) within 5-10 years following the primary surgery. It is possible that asymmetric knee joint loading after unilateral TKA plays a role in contralateral knee osteoarthritis progression. RESEARCH QUESTION: The purpose of this study was to determine differences in peak, cumulative and rate of loading within the compartments of the surgical and non-surgical knees during walking in adults 6 months post-TKA.
methods30 participants underwent gait analysis with marker trajectory and analog data integrated into a musculoskeletal lower body model constructed in OpenSim. Normalized quadriceps/hamstring strength and radiographic alignment of the limbs was integrated into individual musculoskeletal models to improve optimization. Paired t-tests were used to compare differences in knee joint loading between limbs.
resultsFor primary outcomes, significantly greater total (p = 0.01, d=0.48), medial (p = 0.02, d=0.43) and lateral (p = 0.03, d=0.40) compartment peak knee loading was observed in the non-surgical knee compared to the surgical knee during early stance. Significantly greater peak total (p = 0.033, d=0.41) and medial (p = 0.045, d=0.38) compartment knee loading was observed in the non-surgical knee compared to the surgical knee during late stance. For secondary outcomes, greater peak vGRF (p = 0.01, d=0.66), cumulative loading (p = 0.03, d=0.41) and instantaneous loading rate (p = 0.00, d=1.44) were observed in the medial compartment on the non-surgical knee compared to the surgical knee during early stance. Greater peak vGRF (p = 0.01, d=0.66) was noted in the non-surgical limb compared to the surgical limb during late stance.
conclusionPeak knee loading, instantaneous loading rate, cumulative loading, and peak vGRF metrics were all greater on the non-surgical knee compared to the surgical knee post-TKA. These loading asymmetries were greatest for the medial and total joint compartments during early stance phase of the gait cycle leading to potential contralateral knee osteoarthritis progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.