Evidence map›Paper›PMID 40663706›Full record

ArticleDiabetes2025

Impacts of Metabolic Reprogramming on the Onset of Diabetic Nephropathy in Mice With Varying Lias Gene Expression Levels.

Sirui Li, Jiayi Zhou, E Diane Wallace, Brandie M Ehrmann, Jonathon W Homeister, Leighton R James, Nobuyo Maeda, Zhenquan Jia, Xianwen Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sirui LiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Jiayi ZhouDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC.
E Diane WallaceDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Brandie M EhrmannDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Jonathon W HomeisterDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Leighton R JamesDivision of Nephrology, Department of Medicine, Augusta University, Augusta, GA.
Nobuyo MaedaDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-2248-3299
Zhenquan JiaDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC.ORCID 0000-0002-5187-1549
Xianwen YiDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-9320-2020

Funding

MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5M
NHLBI NIH HHS R01 HL049277Xianwen Yi
6 · The paper itself

Abstract

article highlightsMetabolic and energy reprogramming significantly affects renal cell function in diabetic kidney disease (DKD). We developed unique metabolic mouse models with varying levels of lipoic acid synthase (Lias) gene expression and correspondingly varying levels of protein lipoylation and metabolic activity. Using these metabolic mouse models, our study demonstrates that increased protein lipoylation can alleviate DKD through metabolic and energetic regulation. Our unique metabolic mouse models can serve as a preclinical platform to evaluate new therapeutic strategies, ultimately guiding translational studies for patients with DKD.

Indexed as

Diabetic NephropathiesSulfurtransferasesAnimalsDiabetes Mellitus, ExperimentalDisease Models, AnimalKidneyMaleMetabolic ReprogrammingMicelipoic acid synthaseSulfurtransferases

Identifiers

PMID40663706
PMCPMC13053214

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.