Evidence map›Paper›PMID 40663581›Full record

ArticleMenopause (New York, N.Y.)2025

Habitual physical activity and sedentary behavior among women with and without premenopausal bilateral oophorectomy: an exploratory study.

Omid Jahanian, Stacey J Winham, Ekta Kapoor, Walter A Rocca, Nathan LeBrasseur, Kejal Kantarci, Melissa Morrow, Michelle M Mielke, Emma Fortune

Abstract read
In one paragraph

Article in Menopause (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Omid JahanianDivision of Health Care Delivery Research, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery.ORCID 0000-0002-5379-1462
Stacey J WinhamDivision of Computational Biology.
Ekta KapoorDivision of Endocrinology, Diabetes, Metabolism, and Nutrition.
Walter A RoccaWomen's Health Research Center, Mayo Clinic, Rochester, MN.
Nathan LeBrasseurDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN.
Melissa MorrowDepartment of Physical Therapy and Rehabilitation Sciences, Center for Health Promotion, Performance, and Rehabilitation Research, The University of Texas Medical Branch, Galveston, TX.
Michelle M MielkeDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC.
Emma FortuneDivision of Health Care Delivery Research, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MORROW, MELISSA M. · 2018 to 2022
$7.7M
Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2M
Premenopausal bilateral oophorectomy and biomarkers of Alzheimer’s and cerebrovascular diseasesR01AG093767 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI, WALTER A ROCCA · 2025 to 2026
$3.5M
NCATS NIH HHS TL1 TR002371NCATS NIH HHS UL1 TR002377NIA NIH HHS R01 AG093767NIA NIH HHS U54 AG044170NICHD NIH HHS K12 HD065987
6 · The paper itself

Abstract

objectiveTo explore potential differences in physical activity and sedentary behavior volumes and patterns among postmenopausal women with and without premenopausal bilateral oophorectomy (PBO).

methodsWomen with a history of PBO (n = 50) and age-matched postmenopausal referent women (n = 50) were recruited. Participants wore accelerometers on both ankles for 7 days. Volume metrics of sedentary behavior and physical activity, such as step counts, active time, and sedentary time, as well as the sedentary behavior and habitual physical activity distribution, and accumulation patterns, were quantified from the accelerometer data and compared between groups.

resultsMetrics indicating volume of sedentary behavior and physical activity were not statistically different between groups. PBO was significantly associated with higher variability in stepping bout time ( P = 0.022), indicating a potentially more complex walking pattern. In addition, PBO was significantly associated with lower variability in sedentary break time ( P = 0.012), and lower activity time Gini index ( Z = -2.428, P = 0.015). This suggests that women with PBO may have broken up their sedentary time with shorter and less variable activity bouts, and because they had relatively shorter average daily active time, they might be at a higher risk of subsequent adverse health outcomes such as low bone mineral density.

conclusionsAlthough there were no differences in overall activity volume, some differences in activity patterns emerged between women with PBO and referent women. The study highlights the need for longitudinal research to understand how physical activity and sedentary behavior patterns evolve in postmenopausal women with a history of PBO.

Indexed as

ExerciseOvariectomyPremenopauseSedentary BehaviorAccelerometryAdultFemaleHumansMiddle AgedPostmenopausePhysical activityPremenopausal bilateral oophorectomySedentary behaviorWearable sensors

Identifiers

PMID40663581
PMCPMC12991064

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.