ArticlePLoS genetics2025
Four ZIPs contribute to Zn, Fe, Cu and Mn acquisition at the outer root domain.
Article in PLoS genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The transcription factor AtANAC070 enhances zinc tolerance by promoting AtMTP1 expression in Arabidopsis thaliana.Plant cell reports · 2026Article
- Article
- Abiotic Stress Tolerance in Foxtail Millet (Plants (Basel, Switzerland) · 2026Review
- Redox-primed biocontrol application reshapes Fusarium wilt resistance and metal homeostasis in tomato under arid conditions.BMC plant biology · 2026Article
- BjZIP1, a plasma membrane-localized transporter, mediates cadmium and zinc uptake in Brassica juncea.Plant cell reports · 2025Article
- Copper connections: coordinating transport, sensing and systemic signalling in plants.Quantitative plant biology · 2025Review
- Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state.Quantitative plant biology · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Zinc (Zn), an essential micronutrient, plays a crucial role in plant development. However, the specific transporters involved in Zn uptake from the soil remain unclear in dicotyledonous plants. Using promoter-reporter lines in Arabidopsis thaliana, we identified several ZIP (Zn-regulated transporter, Iron-regulated transporter (IRT)-like Protein) family members that are expressed in the epidermis and potentially involved in Zn acquisition from the outer root domain. ZIP2, ZIP3, ZIP5 and ZIP8 predominantly localize to the plasma membrane of epidermal and cortical cells, supporting their potential roles in metal uptake from the soil. Through physiology studies, ionomic profiling and genetic analysis, we determined that ZIP3 and ZIP5 are contributors to Zn acquisition, while ZIP2 and ZIP8 are primarily involved in copper (Cu) and iron (Fe) acquisition respectively. Notably, ZIP3 and ZIP8 exhibit outer polarity in root epidermal cells, similar to IRT1, in agreement with expectations of transporter polarity in mineral acquisition. These findings provide new insights into the mechanisms of metal uptake in plant roots and offer potential strategies for biofortification to enhance metal content in plants.
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