Evidence map›Paper›PMID 40663506›Full record

ArticleJournal of the American Chemical Society2025

Divergent Kinetic/Thermodynamic Selectivity in Palladium(II)-Mediated C-H Activation to Form 5- and 6-Membered Palladacycles.

Philip S Zhou, Kyana M Sanders, Ilia A Guzei, Djamaladdin G Musaev, Shannon S Stahl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Philip S ZhouDepartment of Chemistry, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.
Kyana M SandersDepartment of Chemistry, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-3483-6992
Ilia A GuzeiDepartment of Chemistry, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-1976-7386
Djamaladdin G MusaevCherry L. Emerson Center for Scientific Computation, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0003-1160-6131
Shannon S StahlDepartment of Chemistry, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-9000-7665

Funding

Catalytic Redox Reactions for Pharmaceutical SynthesisR35GM134929 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Shannon S Stahl · 2020 to 2026
$4.3M
Laser-Enhanced NMR Instrumentation for Chemical and Biochemical ResearchS10OD012245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2013 to 2013
$1.0M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
NIGMS NIH HHS R35 GM134929NIH HHS S10 OD012245NIH HHS S10 OD020022
6 · The paper itself

Abstract

Palladium-catalyzed C-H functionalization proceeds via metallacycle formation and often favors 6-membered palladacycles, contrasting the typical preference for 5-membered chelates in transition-metal complexes. The present study probes the origin of this behavior by comparing the reactivity of benzoate and phenylacetate substrates in stoichiometric and catalytic reactions with MPAA-ligated Pd(OAc)

Identifiers

PMID40663506
PMCPMC12376188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.