Evidence map›Paper›PMID 40663498›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2025

Linking Personality Traits to Disability Progression in Multiple Sclerosis: A Longitudinal Analysis.

Isabele Jacot de Alcântara, Philippe Voruz, Gilles Allali, Patrice H Lalive, Julie A Péron

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Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabele Jacot de AlcântaraClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-2033-6287
Philippe VoruzClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-6796-8807
Gilles AllaliLeenaards Memory Center, Lausanne University Hospital and University of Lausanne, Lausanne, Vaud, Switzerland.ORCID 0000-0002-4455-6719
Patrice H LaliveDivision of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
Julie A PéronClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-6579-4011

Funding

Swiss Multiple Sclerosis Society 2023-19
6 · The paper itself

Abstract

objectiveLiving with a chronic disease often involves facing many personal changes. In multiple sclerosis (MS), these changes can occur in both physical and psychological domains. Interestingly, psychological factors, including personality traits, have been suggested as potential contributors to disability progression in MS. However, longitudinal studies exploring these associations are scarce. The objective of this study is to highlight and understand long-term associations between personality and disability progression in MS using advanced statistical methods that provide a robust approach to analyzing repeated measures.

methodsTwenty-eight people with a confirmed diagnosis of MS (Mage = 47.5 years; 19 women) were included in this longitudinal study. Personality was assessed using the NEO-Personality Inventory-3 and disability with the Expanded Disability Status Scale at two time points (mean interval of 4.2 years). Finally, Generalized Estimating Equations were performed.

resultsPersons who displayed an increase in Neuroticism, notably in its Anxiety facet, as well as a decrease in Extraversion, particularly in its Warmth and Gregariousness facets, showed more disability increase.

conclusionThese findings underscore the importance of considering personality dynamics in the management of MS and advocate for a more individualized, person-centered approach to care and research.

Indexed as

Disease ProgressionMultiple SclerosisPersonalityPersons with DisabilitiesAdultDisability EvaluationFemaleHumansLongitudinal StudiesMaleMiddle AgedPersonality Inventorydisabilitygeneralized estimating equationsindividual variabilityMultiple sclerosispersonality

Identifiers

PMID40663498
PMCPMC12644050

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