Evidence map›Paper›PMID 40663469›Full record

ReviewAnnual review of vision science2025

Restoration of Sight with Electronic Retinal Prostheses.

Daniel Palanker, James D Weiland, Boris Rosin, José-Alain Sahel

Abstract readReview
In one paragraph

Review in Annual review of vision science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Neural Vision Restoration in Ophthalmology.Annals of biomedical engineering · 2026
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel PalankerDepartment of Ophthalmology, Stanford University, Stanford, California, USA; email: palanker@stanford.edu.
James D WeilandDepartments of Biomedical Engineering and Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.
Boris RosinDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; email: sahelja@upmc.edu.
José-Alain SahelDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; email: sahelja@upmc.edu.

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Photovoltaic Subretinal Prosthesis with High Pixel DensityR01EY027786 · NEI · STANFORD UNIVERSITY · PI PALANKER, DANIEL V · 2017 to 2021
$3.3M
Electronic photoreceptors for restoration of sight in retinal degenerationR01EY035227 · NEI · STANFORD UNIVERSITY · PI DANIEL V PALANKER · 2023 to 2026
$2.7M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY027786NEI NIH HHS R01 EY035227
6 · The paper itself

Abstract

Retinal prostheses aim at restoring sight to patients blinded by atrophy of photoreceptors using electrical stimulation of the inner retinal neurons. Bipolar cells can be targeted using subretinal implants, and their responses are then relayed to the central visual pathways via the retinal neural network, preserving many features of natural signal processing. Epiretinal implants stimulate the output retinal layer-ganglion cells-and encode visual information directly in spiking patterns.Several companies and academic groups have demonstrated that electrical stimulation of the degenerate retina can elicit visual percepts. However, most failed to consistently and safely achieve an acceptable level of performance. Recent clinical trials demonstrated that subretinal photovoltaic arrays in patients visually impaired by age-related macular degeneration can provide letter acuity matching their 100 μm pixel pitch, corresponding to 20/420 acuity. Electronic zoom enabled patients to read smaller fonts. This review describes the concepts, technologies, and clinical outcomes of current systems and provides an outlook into future developments.

Indexed as

BlindnessElectric Stimulation TherapyRetinaVisual ProsthesisHumansMacular DegenerationVisual Acuityblindnessimplantsprosthesesrehabilitationretinal degenerationsvision restoration

Identifiers

PMID40663469
PMCPMC12994432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.