ArticleMethods in molecular biology (Clifton, N.J.)2025
Fmoc Solid-Phase FIT-PNA Synthesis-Manual and Automated Methodologies.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Gamma-FIT-PNAs as sensitive RNA probes.RSC chemical biology · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peptide nucleic acids (PNA) [1] are synthetic DNA analogs that are used as DNA/RNA mimics for diagnostic [2, 3] and therapeutic purposes [2-5]. One sensing strategy is the use of fluorogenic probes. One such probe is forced intercalation (FIT) PNA, which has a surrogate base as a cyanine dye (e.g., BisQ, TO) that replaces one of the natural bases in the PNA sequence. FIT-PNAs fluoresce after DNA/RNA hybridization, and display sensitivity towards single base mismatches [6]. These, combined with other desirable features, render them highly attractive as RNA/DNA sensors.Herein, we describe the procedure for FIT-PNA synthesis, both by manual and automated methodologies.
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